Results 41 to 50 of about 3,983 (257)

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Process Simulation of a Temperature Swing Absorption Process for Hydrogen Isotope Separation

Energies
Temperature Swing Absorption (TSA) is the primary candidate for the Isotope Rebalancing and Protium Removal (IRPR) system within the envisioned EU-DEMO fusion reactor fuel cycle.
Annika Uihlein, Jonas Caspar Schwenzer, Stefan Hanke, Thomas Giegerich   +3 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Early planetesimal differentiation and late accretion shaped Earth’s nitrogen budget

Nature Communications
The relative roles of protoplanetary differentiation versus late accretion in establishing Earth’s life-essential volatile element inventory are being hotly debated.
Wenzhong Wang, Michael J. Walter, John P. Brodholt, Shichun Huang   +3 more
doaj   +1 more source

A New Customizable Surfactant LLPS Strategy for Sustainable and Highly Efficient Radioactive Metal Ion Separation

Advanced Science, EarlyView.
A diluent‐free, customizable liquid–liquid phase separation (LLPS) platform enables highly efficient radioactive metal ion extraction and stripping. By encapsulating hydrophobic extractants into an ionic surfactant‐rich condensed phase, this LLPS system leverages synergistic electrostatic and coordination interactions.
Ruihan Yan, Yifu Hu, Wentao Wang, Zhi Cao, Meiwen Cao, Weifang Zheng, Guoan Ye, Taihong Yan   +7 more
wiley   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Anthropogenic emissions of volatile Cd detected in western tropical North Atlantic surface seawater

Communications Earth & Environment
The Cd concentrations and isotope compositions of open ocean surface waters are generally thought to be governed by internal cycling, and particularly by the balance between upwelling of more Cd-rich deeper water masses and Cd uptake by phytoplankton ...
Hui Xu, Mark Rehkämper, Yihang Huang, Zijian Jia, Katharina Kreissig, Barry J. Coles, Rebekah E. T. Moore, Arianna Olivelli, Rob Middag, Alex Baker, Rachel Shelley, Tina van de Flierdt   +11 more
doaj   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Volatile Element Depletion of Carbonaceous Chondrites—Insights from Mass-dependent Zinc, Cadmium, and Tellurium Isotope Variations

The Astrophysical Journal
The origin of volatile depletion in the solar system remains a topic of intense debate. To further inform our understanding of the mechanisms involved, this study characterized the mass-dependent Zn, Cd, and Te isotope compositions and concentrations of ...
Elin M. Morton, Harvey Pickard, Frank Wombacher, Yihang Huang, Emeliana Palk, Rayssa Martins, Sven Kuthning, Maria Schönbächler, Mark Rehkämper   +8 more
doaj   +1 more source

Element enrichment and provenance of the detrital component in Holocene sediments from the western Black Sea

Oceanologia, 2020
Summary: Concentrations of a large set of major and trace elements, and Sr, Nd and Pb isotope ratios were measured in Holocene sediments cored in the western deep Black Sea in order to unravel: (1) the controls of element enrichment, and (2) sources of ...
Vesselin M. Dekov, Valentina Y. Darakchieva, Kjell Billström, C. Dieter Garbe-Schönberg, George D. Kamenov, Morgane Gallinari, Lyubomir Dimitrov, Olivier Ragueneau, Ellen Kooijman   +8 more
doaj   +1 more source