Results 61 to 70 of about 3,983 (257)

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Effect of esomeprazole on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study is to evaluate the effects of multiple doses of esomeprazole, a strong proton pump inhibitor and acid‐reducing agent, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader.
Lana Tran, Naihan Chen, Jennifer A. Winton, Kyle T. Matschke, Smita P. Goodman, Kimberly C. Lee, Yuanyuan Zhang, Weiwei Tan   +7 more
wiley   +1 more source

Innovative laser-based methods for monitoring fuel retention in ITER

Nuclear Materials and Energy
This paper addresses the challenge of tritium inventory management in ITER and future fusion reactors, highlighting the importance of accurate tritium measurement and its spatial distribution within the vacuum vessel. Given ITER’s operational constraints,
A. Huber, Ph. Andrew, G. Sergienko, J. Assmann, D. Castano, A. De Schepper, S. Friese, R. Greven, I. Ivashov, D. Kampf, Y. Krasikov, C.C. Klepper, H.T. Lambertz, Ph. Mertens, K. Mlynczak, G. Offermanns, B. Quinlan, K. Rasinska, M. Schrader, D. Van Staden, A. Terra, Xi Jiang, M. Zlobinski, V. Huber, A. Reutlinger, S. Brezinsek, Ch. Linsmeier   +26 more
doaj   +1 more source

The influence of rivers on seabird foraging ecology

Biological Reviews, EarlyView.
ABSTRACT Rivers act as vital arteries to the world's oceans, delivering fresh water and nutrients that sustain marine ecosystems. Globally, river flow increasingly is being altered by climate change and anthropogenic pressures; yet the significance of rivers to predatory marine species, such as seabirds, and the extent to which river‐related changes ...
Julia B. Morais, Andre Chiaradia, Richard D. Reina   +2 more
wiley   +1 more source

Incorporating ¹⁵N into the Multi-Resolution Emission Inventory to Simulate the Spatiotemporal Variations of δ¹⁵N in Emitted NO_x over the Pearl River Delta Region, China

Atmosphere
Nitrogen oxides (NOx), comprising nitric oxide (NO) and nitrogen dioxide (NO2), are key precursors of atmospheric nitrate, a major component of fine particulate matter (PM2.5) that critically affects air quality, human health, and ecosystems.
Fan Wang, Yiming Liu, Greg Michalski, Wendell Walters, Huan Fang   +4 more
doaj   +1 more source

Prospective trial comparing intraoperative flexible, rigid, and no cystoscopy after ultrasound-guided transperineal permanent seed prostate brachytherapy

Urological Science, 2016
Objective: This is a prospective trial comparing the impact of intraoperative flexible, rigid, and no cystoscopy on dysuria immediately after permanent seed prostate brachytherapy (PB).
John Sylvester, Matthew Perry, Erik Togerson, Jason Hinton   +3 more
doaj   +1 more source

Breaking the Mold: Electrophilic Hydrophosphanation Emerges

Chemistry – A European Journal, EarlyView.
Electrophilic hydride attack on the olefin, instead of the classical nucleophilic addition by a phosphanido ligand, is unveiled in rhodium‐catalyzed olefin hydrophosphanation. This hydride‐driven pathway operates for both activated and inactivated olefins, with transition states characterized by elongated Rh─H bonds and nascent C─H bond formation ...
Víctor Varela‐Izquierdo, Janeth Navarro, Judit Cano‐Asensio, José A. López, Cristina Tejel   +4 more
wiley   +1 more source

Modelling fuel retention in the W divertor during the D/H/D changeover experiment in WEST

Nuclear Materials and Energy
A fuelling changeover experiment from Deuterium (D) to Hydrogen (H), and back has been performed in WEST to study the retention and removal in metallic devices with actively cooled ITER-grade tungsten divertor.
E.A. Hodille, D. Piccinelli, M. Bertoglio, T. Loarer, J. Dufour, J. Denis, E. Lascar, G. Ciraolo, P. Tamain, Y. Ferro, E. Geulin, A. Gallo, P. Moreau, S. Vartanian, R. Bisson, B. Pégourié, Y. Anquetin, J. Gaspar, Y. Corre, K. Dunnell, T. Wauters   +20 more
doaj   +1 more source

Membrane Processes for the Nuclear Fusion Fuel Cycle

Membranes, 2018
This paper reviews the membrane processes for the nuclear fusion fuel cycle—namely, the treatment of the plasma exhaust gases and the extraction of tritium from the breeding blankets.
Silvano Tosti, Alfonso Pozio
doaj   +1 more source