Results 141 to 150 of about 1,839,261 (340)

Fully Automated Deep Learning Enabled Miniature Mass Spectrometry System for Psychoactive Therapeutic Drug Monitoring

open access: yesAdvanced Science, EarlyView.
This study presents a fully automated miniature mass spectrometry system for high‐throughput therapeutic drug monitoring. Integrating magnetic solid‐phase extraction, self‐aspiration sampling miniature mass spectrometer, and U‐net deep learning quantitative algorithm, it achieves rapid (8 samples/30 min), precise (R2 > 0.99, RSD < 10%), and portable ...
Yuanhao Zhou   +10 more
wiley   +1 more source

Stable isotope labeling as a promising tool for rapid drug susceptibility testing in Neisseria gonorrhoeae. [PDF]

open access: yesBraz J Microbiol, 2023
Dadwal R   +8 more
europepmc   +1 more source

Glucose‐Responsive PAGR1‐Regulated Skeletal Muscle Gene Program Controls Systemic Glucose Homeostasis and Hepatic Metabolism

open access: yesAdvanced Science, EarlyView.
The study reveals that PAXIP1‐associated glutamate‐rich protein 1 (PAGR1), a glucose‐responsive regulator in skeletal muscle, modulates systemic glucose homeostasis and hepatic metabolism. Muscle‐specific PAGR1 deletion enhances insulin signaling, promotes glucose transporter 4 (GLUT4) translocation, and protects against high‐fat‐diet‐induced insulin ...
Chenyun Ding   +19 more
wiley   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

open access: yesAdvanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen   +9 more
wiley   +1 more source

Isotope Labeling and Biochemical Assessment of Liver-Triacylglycerol in Patients with Different Levels of Histologically-Graded Liver Disease. [PDF]

open access: yesJ Nutr, 2023
Syed-Abdul MM   +8 more
europepmc   +1 more source

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