Results 281 to 290 of about 48,742 (295)

Synthesis of isotopically labeled (+)-deoxypyridinoline

Journal of Labelled Compounds and Radiopharmaceuticals, 2000
An efficient synthesis of isotopically labeled (+)-deoxypyridinoline (3) was achieved via quaternization of (S,S)(−)-4 with (S)-(−)-iodide (5) and subsequent hydrolysis. The required (S)-(−)-iodide (5) was prepared from a commercially available (S)-5-(tert-butoxy)-4-[tert-butoxycarbonyl)amino]-5-oxopentanoic acid (6) in seven steps and good overall ...
Maciej Adamczyk, Donald D. Johnson, Rajarathnam E. Reddy, Sushil D. Rege   +3 more
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Production of Isotopically Labeled KRAS4b

Isotopically labelled proteins are important reagents in structural biology as well as in targeted drug development. The field continues to advance with complex multi-isotope labeling. We have combined our experience in high-level soluble KRAS4b expression with protocols for isotope incorporation, to achieve reliable and efficient approaches for ...
Troy, Taylor, William, Gillette
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Isotopic labelings for mechanistic studies

The intricate mechanisms in the biosynthesis of terpenes belong to the most challenging problems in natural product chemistry. Methods to address these problems include the structure-based site-directed mutagenesis of terpene synthases, computational approaches, and isotopic labeling experiments. The latter approach has a long tradition in biosynthesis
Houchao, Xu, Jeroen S, Dickschat
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Quantification of Isotope Label [PDF]

, 2008
R. G. Ratcliffe, Doug K. Allen
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ICPL—Isotope-Coded Protein Label

2008
Stable isotope labeling in combination with mass spectrometry has emerged as a powerful tool to identify and relatively quantify thousands of proteins within complex protein mixtures. Here we describe a method, termed isotope-coded protein label (ICPL), which is capable of high-throughput quantitative proteome profiling on a global scale.
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Mapping isotopically labeled alanine

Science, 2019
Electron Microscopy Electron microscopy of organic materials must avoid the destructive effects of electron beam impact. One approach is to measure vibrational spectra with electron energy-loss spectroscopy in a mode where the electron beam grazes the sample and couples to it through evanescent modes. Hachtel et al. used such methods to probe carbon-12–
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Labelling Locusts with Radioactive Isotopes

Nature, 1955
FOLLOWING successful attempts at marking Lepidopterous larvae with radioactive sulphur with the object of investigating population dynamics, larval death-rate, and dispersal1, an opportunity presented itself of applying similar principles to locusts (Locusta migratoria L. and Locustana pardalina Walk.).
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ChemInform Abstract: Radiopharmaceuticals Labelled with Bromine Isotopes

ChemInform, 1986
Bernard Maziere, Christian Loc'h
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Isotope labeling in Biomolecular NMR

2012
PROTEINS 1. Isotope labeling methods for large systems Patrik Lundstrom, Alexandra Ahlner and Annica Theresia Blissing 2. Segmental labeling to study multidomain proteins Jing Xue, David S. Burz and Alexander Shekhtman 3. Isotope Labeling for Solution and Solid-State NMR Spectroscopy of Membrane Proteins Raffaello Verardi, Nathaniel J.
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Isotopic Labelling in Mass Spectrometry

1999
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