Explicit kinetic heterogeneity: mechanistic models for interpretation of labeling data of heterogeneous cell populations [PDF]
Estimation of division and death rates of lymphocytes in different conditions is vital for quantitative understanding of the immune system. Deuterium, in the form of deuterated glucose or heavy water, can be used to measure rates of proliferation and ...
Angela R. McLean +27 more
core +9 more sources
Ultra-sensitive isotope probing to quantify activity and substrate assimilation in microbiomes
Background Stable isotope probing (SIP) approaches are a critical tool in microbiome research to determine associations between species and substrates, as well as the activity of species. The application of these approaches ranges from studying microbial
Manuel Kleiner +10 more
doaj +1 more source
Potential uptake of dissolved organic matter by seagrasses and macroalgae [PDF]
Dissolved organic nitrogen (DON) acts as a large reservoir of fixed nitrogen. Whereas DON utilization is common in the microbial community, little is known about utilization by macrophytes.
Bouma, Tjeerd J. +8 more
core +5 more sources
Synthesis of isotopically labeled epothilones [PDF]
The epothilones, including epothilones B and D, are macrocyclic lactones, which have potent cytotoxicities and promote the polymerization of tubulin to mictotubules by binding to and stabilizing the tubulin polymer. They have a very similar mechanism of action to paclitaxel (Taxol®).
Thota, Ganesh +4 more
openaire +2 more sources
Real-time quantitative analysis of volatile products generated during solid-state polypropylene thermal oxidation [PDF]
Analysis of volatile organic compounds (VOCs) during PP thermal oxidation under three oxygen partial pressures (0%, 21% and 100% of atmospheric pressure) at 140 C was performed by proton transfer reaction coupled with Fourier transform ion cyclotron ...
COLIN, Xavier +6 more
core +4 more sources
Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives. [PDF]
Human neutrophils have traditionally been thought to have a short half-life in blood; estimates vary from 4-18 hours. This dogma was recently challenged by stable isotope labeling studies with heavy water which yielded estimates in excess of 3 days.
Akbulut +61 more
core +1 more source
zmm28 transgenic maize increases both N uptake- and N utilization-efficiencies
Isotope 15N labeling demonstrates that zmm28 transgenic maize have an improved N uptake during late-vegetative stages inducing N storage in lower leaves of the canopy and, thus, N uptake efficiency relative to wild-type maize.
Javier A. Fernandez +6 more
doaj +1 more source
The accuracy of stable isotope tracing techniques, traditional and reverse labeling, in evaluating metal bioavailability remains uncertain. This study employed pulse-chase feeding combined with multi-heavy-metal stable isotope labeling to compare the ...
Yunuo Duan +6 more
doaj +1 more source
Binary stable isotope labeling couple with LC-ESI-MS has been used as a powerful non-targeted approach for the relative quantification of lipids, amino acids, and many other important metabolite classes.
Richard G. Torde +4 more
doaj +1 more source
Determination and Analysis of 16 Mycotoxins in Medicinal and Edible Traditional Chinese Medicine
Objective: An analytical method was established for the determination of 16 mycotoxins in traditional Chinese medicines (TCM) by isotope labeling-ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), and 483 medicinal and edible ...
Fenghua LI +7 more
doaj +1 more source

