Results 11 to 20 of about 45,524 (260)
Scientific Data, 2023 Metabolic stable isotope labeling with heavy water followed by liquid chromatography coupled with mass spectrometry (LC-MS) is a powerful tool for in vivo protein turnover studies.
Henock M. Deberneh +8 more
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Journal of Magnetic Resonance Open, 2022 In this work a rapid RNA assignment approach by combining chemical and enzymatic 13C and 15N stable isotope labeling is introduced. We exemplify the assignment strategy for imino N1H1 purine and N3H3 pyrimidine and aromatic C6H6 pyrimidine, C8H8 purine ...
David Klingler +3 more
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Synthesis of isotopically labeled epothilones [PDF]
Journal of Labelled Compounds and Radiopharmaceuticals, 2013 The epothilones, including epothilones B and D, are macrocyclic lactones, which have potent cytotoxicities and promote the polymerization of tubulin to mictotubules by binding to and stabilizing the tubulin polymer. They have a very similar mechanism of action to paclitaxel (Taxol®).
Thota, Ganesh +4 more
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Envelope: interactive software for modeling and fitting complex isotope distributions
BMC Bioinformatics, 2008 Background An important aspect of proteomic mass spectrometry involves quantifying and interpreting the isotope distributions arising from mixtures of macromolecules with different isotope labeling patterns.
Sykes Michael T, Williamson James R
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Stable isotopic labeling in proteomics [PDF]
PROTEOMICS, 2008 AbstractLabeling of proteins and peptides with stable heavy isotopes (deuterium, carbon‐13, nitrogen‐15, and oxygen‐18) is widely used in quantitative proteomics. These are either incorporated metabolically in cells and small organisms, or postmetabolically in proteins and peptides by chemical or enzymatic reactions.
Gevaert, Kris +5 more
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PLoS ONE, 2022 Solution NMR spectroscopy is a well-established tool with unique advantages for structural studies of RNA molecules. However, for large RNA sequences, the NMR resonances often overlap severely.
Hannes Feyrer +4 more
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Research Progress in Radioiodine Labeling Methods of Biomolecules
Journal of Isotopes, 2023 Radiopharmaceuticals derived from targeted molecules labeled with radioiodine have always been the research hotspots in the field of nuclear medicine. Radioiodine labeling also has a clear application demand in pharmacokinetic research.
WANG Yang;LI Zheng;LIU Yuxia;ZHANG Lan;LI Qingnuan
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Isotope Labeling in Mammalian Cells [PDF]
, 2011 Isotope labeling of proteins represents an important and often required tool for the application of nuclear magnetic resonance (NMR) spectroscopy to investigate the structure and dynamics of proteins. Mammalian expression systems have conventionally been considered to be too weak and inefficient for protein expression.
Arpana, Dutta +3 more
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ISOTOPIC LABELLING OF THE MOUSE BLASTOCYST [PDF]
Reproduction, 1968 In the implanting blastocyst of the mouse, the first trophoblast cells to penetrate the uterine epithelium contain large basophil inclusions. It has been suggested that these inclusions originate at an earlier stage within cells of the inner mass which move into the trophoblast just after disintegration of the zona pellucida (Wilson, 1963; Potts & ...
I B, Wilson, M S, Smith
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Bio-Protocol, 2018 Stable-isotope labeled metabolic analysis is an essential methodology to characterize metabolic regulation during biological processes. However, the method using stable-isotope-labeled tracer (e.g., 13C-glucose) in live animal is only beginning to be ...
Yuping Cai, Nan Liu, Zheng-Jiang Zhu
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