Results 11 to 20 of about 480,870 (312)
A Platform for Multiple Isotope Labeling via Carbon-Sulfur Bond Exchange [PDF]
, 2023 Isotopes are at the foundation of applications in life science such as nuclear imaging and are essential tools for the determination of pharmacokinetic and dynamic profiles of new pharmaceuticals.
Antoine , Sallustrau +5 more
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GPCR structural characterization by NMR spectroscopy in solution
Acta Biochimica et Biophysica Sinica, 2022 In the human proteome, 826 G-protein-coupled receptors (GPCRs) interact with extracellular stimuli to initiate cascades of intracellular signaling. Determining conformational dynamics and intermolecular interactions are key to understand GPCR function as
Yang Lingyun +2 more
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Envelope: interactive software for modeling and fitting complex isotope distributions
BMC Bioinformatics, 2008 Background An important aspect of proteomic mass spectrometry involves quantifying and interpreting the isotope distributions arising from mixtures of macromolecules with different isotope labeling patterns.
Sykes Michael T, Williamson James R
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PLoS ONE, 2022 Solution NMR spectroscopy is a well-established tool with unique advantages for structural studies of RNA molecules. However, for large RNA sequences, the NMR resonances often overlap severely.
Hannes Feyrer +4 more
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Synthesis of isotopically labeled epothilones [PDF]
Journal of Labelled Compounds and Radiopharmaceuticals, 2013 The epothilones, including epothilones B and D, are macrocyclic lactones, which have potent cytotoxicities and promote the polymerization of tubulin to mictotubules by binding to and stabilizing the tubulin polymer. They have a very similar mechanism of action to paclitaxel (Taxol®).
Thota, Ganesh +4 more
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Stable isotopic labeling in proteomics [PDF]
PROTEOMICS, 2008 AbstractLabeling of proteins and peptides with stable heavy isotopes (deuterium, carbon‐13, nitrogen‐15, and oxygen‐18) is widely used in quantitative proteomics. These are either incorporated metabolically in cells and small organisms, or postmetabolically in proteins and peptides by chemical or enzymatic reactions.
Gevaert, Kris +5 more
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Research Progress in Radioiodine Labeling Methods of Biomolecules
Journal of Isotopes, 2023 Radiopharmaceuticals derived from targeted molecules labeled with radioiodine have always been the research hotspots in the field of nuclear medicine. Radioiodine labeling also has a clear application demand in pharmacokinetic research.
WANG Yang;LI Zheng;LIU Yuxia;ZHANG Lan;LI Qingnuan
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Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans. [PDF]
, 2005 Vitamin A deficiency is a major global public health problem. Among the variety of techniques that are available for assessing human vitamin A status, evaluating the provitamin A nutritional values of foodstuffs and estimating human vitamin A ...
Judy D Ribaya-Mercado +19 more
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ISOTOPIC LABELLING OF THE MOUSE BLASTOCYST [PDF]
Reproduction, 1968 In the implanting blastocyst of the mouse, the first trophoblast cells to penetrate the uterine epithelium contain large basophil inclusions. It has been suggested that these inclusions originate at an earlier stage within cells of the inner mass which move into the trophoblast just after disintegration of the zona pellucida (Wilson, 1963; Potts & ...
I B, Wilson, M S, Smith
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AccuCor2: isotope natural abundance correction for dual-isotope tracer experiments [PDF]
, 2021 Stable isotope labeling techniques have been widely applied in the field of metabolomics and proteomics. Before the measured mass spectral data can be used for quantitative analysis, it must be accurately corrected for isotope natural abundance and ...
Wang, Yujue +5 more
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