Results 31 to 40 of about 45,524 (260)
Chemoenzymatic Assembly of Isotopically Labeled Folates [PDF]
Journal of the American Chemical Society, 2017 Pterin-containing natural products have diverse functions in life, but an efficient and easy scheme for their in vitro synthesis is not available. Here we report a chemoenzymatic 14-step, one-pot synthesis that can be used to generate 13C- and 15N-labeled dihydrofolates (H2F) from glucose, guanine, and p-aminobenzoyl-l-glutamic acid.
Antonio Angelastro +4 more
openaire +6 more sources
Environment InternationalThe accuracy of stable isotope tracing techniques, traditional and reverse labeling, in evaluating metal bioavailability remains uncertain. This study employed pulse-chase feeding combined with multi-heavy-metal stable isotope labeling to compare the ...
Yunuo Duan +6 more
doaj +1 more source
The Rules of Human T Cell Fate in vivo
Frontiers in Immunology, 2020 The processes governing lymphocyte fate (division, differentiation, and death), are typically assumed to be independent of cell age. This assumption has been challenged by a series of elegant studies which clearly show that, for murine cells in vitro ...
Pedro Costa del Amo +9 more
doaj +1 more source
zmm28 transgenic maize increases both N uptake- and N utilization-efficiencies
Communications Biology, 2022 Isotope 15N labeling demonstrates that zmm28 transgenic maize have an improved N uptake during late-vegetative stages inducing N storage in lower leaves of the canopy and, thus, N uptake efficiency relative to wild-type maize.
Javier A. Fernandez +6 more
doaj +1 more source
Determination and Analysis of 16 Mycotoxins in Medicinal and Edible Traditional Chinese Medicine
Shipin gongye ke-ji, 2022 Objective: An analytical method was established for the determination of 16 mycotoxins in traditional Chinese medicines (TCM) by isotope labeling-ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), and 483 medicinal and edible ...
Fenghua LI +7 more
doaj +1 more source
Molecules, 2013 Binary stable isotope labeling couple with LC-ESI-MS has been used as a powerful non-targeted approach for the relative quantification of lipids, amino acids, and many other important metabolite classes.
Richard G. Torde +4 more
doaj +1 more source
Science and Technology of Advanced Materials, 2017 We report the mechanistic investigation of catalytic H2 evolution from formic acid in water using a formate-bridged dinuclear Ru complex as a formate hydrogen lyase model.
Taisuke Tokunaga +5 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Pyridine-based strategies towards nitrogen isotope exchange and multiple isotope incorporation
Nature CommunicationsIsotopic labeling is at the core of health and life science applications such as nuclear imaging, metabolomics and plays a central role in drug development. The rapid access to isotopically labeled organic molecules is a sine qua non condition to support
Minghao Feng +9 more
doaj +1 more source