Results 51 to 60 of about 154,472 (297)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Research Advance of Chlorine Isotope Analytical Techniques

Journal of Isotopes
Chlorine is widely distributed in nature as a major and minor constituent in natural water bodies and salt deposits. The isotopic composition of chlorine serves as a key tracer for understanding the cycling processes of chlorine，and has been extensively ...
Xiangzhe ZENG, Xijie YIN, Shanshan LIN, Yuhong LI   +3 more
doaj   +1 more source

Quantifying precision and accuracy of measurements of dissolved inorganic carbon stable isotopic composition using continuous-flow isotope-ratio mass spectrometry [PDF]

, 2014
RATIONALE: We describe an analytical procedure that allows sample collection and measurement of carbon isotopic composition (δ13CV-PDB value) and dissolved inorganic carbon concentration, [DIC], in aqueous samples without further manipulation post field
Altman, AMCTB, Analytical Methods Committee, AMCTB, Analytical Methods Committee, Assayag, Atekwana, Barth, Bass, Bass, Bouillon, Brandes, Capasso, Cole, Finlay, Finlay, Geldern, Jones, Klein Gebbinck, Maberly, McCrea, Neter, Polsenaere, Salata, Soulsby, Spötl, St-Jean, Taipale, Torn, Torres, Waldron, Yang   +29 more
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Mixed‐mode chromatography/isotope ratio mass spectrometry

Rapid Communications in Mass Spectrometry, 2010
Abstract Liquid chromatography coupled to molecular mass spectrometry (LC/MS) has been a standard technique since the early 1970s but liquid chromatography coupled to high‐precision isotope ratio mass spectrometry (LC/IRMS) has only been available commercially since 2004.
openaire   +3 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

The Use of Stable Isotope Ratio Analysis to Trace European Sea Bass (D. labrax) Originating from Different Farming Systems

Animals, 2020
This study aimed to determine whether isotopic ratio mass spectrometry (IRMS) can discriminate farmed European sea bass according to different farming systems and geographic origins.
Francesca Tulli, José M. Moreno-Rojas, Concetta Maria Messina, Angela Trocino, Gerolamo Xiccato, José M. Muñoz-Redondo, Andrea Santulli, Emilio Tibaldi   +7 more
doaj   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Recent developments in isotope-ratio mass spectrometry for geochemistry and cosmochemistry

, 2016
Mass spectrometry is fundamental to measurements of isotope ratios for applications in isotope geochemistry, geochronology, and cosmochemistry. Magnetic-sector mass spectrometers are most common because these provide the best precision in isotope ratio ...
Ireland, Trevor
core   +1 more source

Accurate and precise quantification of Cu,Zn-SOD in human red blood cells using species-specific double and triple IDMS [PDF]

, 2016
Acknowledgements This research was undertaken within the EMRP project HLT05. The EMRP was jointly funded by the EMRP participating countries within EURAMET and the European Union.
Feldmann, Jorg, Gleitzmann, Julia, Raab, Andrea, Schulze, Dirk, Swart, Claudia, Waetzig, Hermann   +5 more
core   +1 more source