Results 131 to 140 of about 128,867 (311)

Carbon-isotope stratigraphic correlations in the Late Permian [PDF]

open access: bronze, 1986
William T. Holser   +2 more
openalex   +1 more source

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao   +10 more
wiley   +1 more source

Energetic convergence drives metabolic adaptation in lirima chilean high-altitude hydrothermal system

open access: yesCommunications Earth & Environment
High-altitude hydrothermal systems provide laboratories for understanding microbial adaptation to extreme conditions. Here we investigated thermodynamic controls on metabolic transitions in Lirima hydrothermal system (Chile, 4000 meters above sea level ...
Pablo Paquis   +13 more
doaj   +1 more source

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

open access: yesAdvanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang   +9 more
wiley   +1 more source

A Synergistic Complexation‐Encapsulation Paradigm Enables Unprecedented Radioactive Remediation

open access: yesAdvanced Science, EarlyView.
A novel HDEHP‐APG eutectic mixture‐based detergent is developed that achieves highly efficient decontamination of Am through a synergistic complexation‐encapsulation mechanism. Remarkably, such a detergent effectively removes radionuclides across a wide range of oxidation states (+I to +VII), demonstrating exceptional versatility.
Qilong Tang   +4 more
wiley   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

open access: yesAdvanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun   +16 more
wiley   +1 more source

(Figure 2) Stable carbon and oxygen isotope records of ODP Site 208-1262

open access: green, 2010
James C. Zachos   +4 more
openalex   +2 more sources

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