Results 121 to 130 of about 13,316 (289)

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

First Detection of CO Isotopologues in a High-redshift Main-sequence Galaxy: Evidence of a Top-heavy Stellar Initial Mass Function

The Astrophysical Journal
Recent observations and theories have presented a strong challenge to the universality of the stellar initial mass function (IMF) in extreme environments. A notable example has been found for starburst conditions, where evidence favors a top-heavy IMF, i.
Ziyi Guo, Zhi-Yu Zhang, Zhiqiang Yan, Eda Gjergo, Allison W. S. Man, R. J. Ivison, Xiaoting Fu, Yong Shi   +7 more
doaj   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Measuring the 34S and 33S Isotopic Ratios of Volatile Sulfur during Planet Formation

The Astrophysical Journal
Stable isotopic ratios constitute powerful tools for unraveling the thermal and irradiation history of volatiles. In particular, we can use our knowledge of the isotopic fractionation processes active during the various stages of star, disk, and planet ...
Alice S. Booth, Maria N. Drozdovskaya, Milou Temmink, Hideko Nomura, Ewine F. van Dishoeck, Luke Keyte, Charles J. Law, Margot Leemker, Nienke van der Marel, Shota Notsu, Karin Öberg, Catherine Walsh   +11 more
doaj   +1 more source

(Table 3) Offsets of isotopic values, in non-biogenic silica contamination and differences in the relative abundance of spring/summer species in sediment core MD01-2416

, 2001
Edith Maier, Bernhard Chapligin, Andrea Abelmann, Rainer Gersonde, Oliver Esper, Jian Ren, Hans Friedrichsen, Hanno Meyer, Ralf Tiedemann   +8 more
openalex   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Effect of the Energy of Consciousness (The Trivedi Effect®) on the Structural Properties and Isotopic Abundance Ratio of Magnesium Gluconate Using LC-MS and NMR Spectroscopy

, 2017
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Wellborn, Barry Dean, Smith, Deborah Lea, Koster, Dezi Ann, Patric, Elizabeth, Singh, Jagdish, Vagt, Kathleen Starr, Callas, Krista Joanne, Panda, Parthasarathi, Sethi, Kalyan Kumar, Jana, Snehasis   +13 more
openalex   +1 more source

Microdroplet Stabilization Enabled Direct Mass Spectrometric Identification of Electrogenerated Transient Carbocation Intermediates

Advanced Science, EarlyView.
The in situ mass spectrometric identification of the electrogenerated benzylic and phenylic carbocations, whose half‐lives in bulk solutions are on the nanosecond scale, is achieved by taking advantage of the unique stabilization effect of the electrosprayed microdroplets.
Guo‐Shan Zhu, Ren‐Jie Hui, Jun Hu
wiley   +1 more source

Structure‐Function Integration in 2D Hybrid Perovskite for Fast Neutron and Gamma Ray Discrimination

Advanced Science, EarlyView.
Using an in situ seed‐assisted cooling method, large (28 × 7 × 3 mm3) (GABA)2PbBr4 single crystals are grown, featuring hydrogen‐rich organic layers and a dense PbBr4 framework. This architecture enables efficient γ‐ray absorption, fast‐neutron sensitivity, and clear n/γ pulse‐shape discrimination (FOM up to 1.74), highlighting its potential as a ...
Yingming Wang, Lingyan Xu, Chongqi Liu, Lu Liang, Binghui Zhang, Zhentao Qin, Lixiang Lian, Wei Zheng, Yanyan Lei, Qinzeng Hu, Shuai Song, Chaopeng Mi, Tao Wang, Yadong Xu, Gangqiang Zha, Wanqi Jie   +15 more
wiley   +1 more source