Results 161 to 170 of about 60,044 (291)

Radical‐Based On‐Surface Transformation of Nonplanar Aromatics Into Nonbenzenoid Nanographenes

Angewandte Chemie, EarlyView.
Formation of radicals in nonplanar hydrocarbons through thermally induced dehydrogenation leads to molecular transformation via intramolecular radical‐based cyclization and dimerization, leading to formation of nonbenzenoid nanographenes. ABSTRACT On‐surface synthesis has emerged as a powerful tool for atomically precise C─C bond formation, enabling ...
Daniel Rothhardt, Ming‐Lun Pan, Michael Píro, Stefan Niklaus Heinen, Christian Wäckerlin, Hans Josef Hug, Yao‐Ting Wu, Karl‐Heinz Ernst, Miloš Baljozović   +8 more
wiley   +2 more sources

CSF‐Compartmentalized Antibody Glycoprofiles in NMDAR Encephalitis Associate with Etiology and Functional Recovery

Annals of Neurology, EarlyView.
Objective To characterize Fc‐glycosylation profiles in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis (NMDARe) and assess their association with antibody compartmentalization (cerebrospinal fluid [CSF] vs serum), disease triggers (viral, tumor‐related or idiopathic), and 1‐year outcomes.
Laura Marmolejo, Claudia Papi, Chiara Milano, Esther Aguilar, Estibaliz Maudes, Ivana Duvnjak Orešković, Jerko Štambuk, Maja Pučić‐Baković, Gemma Olivé‐Cirera, Elianet Fonseca, Mar Guasp, Eugenia Martinez‐Hernandez, Helena Ariño, Takahiro Iizuka, Thais Armangué, Josep Dalmau, Marianna Spatola   +16 more
wiley   +1 more source

Two‐Dimensional Infrared Spectroscopy Reveals the Presence of a Bridging CO Ligand in Two Catalytic Intermediates of [FeFe] Hydrogenase

Angewandte Chemie, EarlyView.
Two‐dimensional (2D) infrared (IR) spectroscopy provides vastly more structural and functional insight into chemical and biological systems than linear IR spectroscopy. Here, we apply 2D‐IR spectroscopy to two controversially discussed states of the [FeFe] hydrogenase active site, revealing the presence of a bridging carbonyl ligand, which is difficult
Cornelius C. M. Bernitzky, Mathesh Vaithiyanathan, Manon T. Lachmann, Igor V. Sazanovich, Gregory M. Greetham, Patricia Rodríguez‐Maciá, James A. Birrell, Marius Horch   +7 more
wiley   +2 more sources

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Programming Palladium Cage Geometry through Ligand Redox Modulation

Angewandte Chemie, EarlyView.
A neutral redox‐active exTTF ligand (L) forms a Pd2L4 cage, whereas its oxidized form (Lox) yields a Pd2(Lox)2 macrocycle. Lox further assembles with a dibenzothiophene derivative (L′) into Pd2(Lox)(L′)2 and Pd4(Lox)4(L′)4 architectures. Reduction of Pd2(Lox)2 and Pd2(Lox)(L′)2 restores the parent Pd2L4 cage, enabling redox controlled nuclearity ...
Jennifer Bou Zeid, Jean Nicolas, Maksym Dekhtiarenko, David Canevet, Magali Allain, Vincent Carré, Frédéric Aubriet, Laura Neukirch, Elie Benchimol, Marc Sallé, Guido H. Clever, Sébastien Goeb   +11 more
wiley   +2 more sources

Biomarkers on the Icy Jovian Moons: Can Europa Also Provide Insights into Life's Origin? [PDF]

Life (Basel)
Chela-Flores J, Lancet D, Yaniv R.
europepmc   +1 more source

Spatial Detection of Microsphere Polystyrene Plastics and Molecular Remodeling within a Full‐Body Mouse with MALDI Trapped Ion Mobility Mass Spectrometry Imaging

Angewandte Chemie, EarlyView.
Orally administered polystyrene microplastics accumulate in murine tissues and are detected using MALDI‐MSI with TIMS. Lipid profiling reveals decreases in hexosylceramides, sphingomyelins, and ether‐linked phospholipids, indicating altered metabolism.
Karina A. Vargas, Amy L. Parkhurst, Ming‐Fo Hsu, Christopher Hou, Fawaz G. Haj, Elizabeth K. Neumann   +5 more
wiley   +2 more sources

Multiple formation pathways for amino acids in the early Solar System based on carbon and nitrogen isotopes in asteroid Bennu samples. [PDF]

Proc Natl Acad Sci U S A
Baczynski AA, Mcintosh OM, Simkus DN, McLain HL, Dworkin JP, Glavin DP, Elsila JE, Matney M, House CH, Freeman KH, Connolly HC, Lauretta DS.   +11 more
europepmc   +1 more source

A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation

Angewandte Chemie, EarlyView.
The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Sebastian Dörner, Kai Rogge, Felix Trottmann, Christian Hertweck, Dirk Hoffmeister   +4 more
wiley   +2 more sources

Matrix-Tolerant Quantification of THC and THCA in Complex Cannabis Products Using In-Sample Calibration with Multiple Isotopologue Reaction Monitoring. [PDF]

J Am Soc Mass Spectrom
Li Y, Zhang M.
europepmc   +1 more source