Results 161 to 170 of about 70,014 (336)

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg   +7 more
wiley   +1 more source

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang   +5 more
wiley   +1 more source

Selective Synthesis of N,N‐Dimethylformamide From CO2 Hydrogenation Coupled With Dimethylamine Over a ZnZrOx Solid‐Solution Catalyst

open access: yesCarbon and Hydrogen, EarlyView.
N‐formylation of dimethylamine though CO2 hydrogenation takes place at a ZnZrOx solid‐solution catalyst surface toward N,N‐dimethylformamide. By synergistic effect of Zn and Zr sites, the catalyst achieves 99% DMF selectivity at 14% DMA conversion at 280°C with at least 1000 h stability on steam.
Jinxin He   +10 more
wiley   +1 more source

Carbon‐14 Perovskite Betavoltaics Reach Record 10.79% Efficiency

open access: yesCarbon Energy, EarlyView.
A perovskite‐based betavoltaic cell incorporating carbon‐14 nanoparticles and formamidinium lead iodide achieves a record energy conversion efficiency of 10.79%. The device design enhances charge generation through an electron avalanche multiplication mechanism.
Hong Soo Kim   +6 more
wiley   +1 more source

Copper(II), a Peculiar Metal Ion for Complexation with Monensin A Ionophore

open access: yesChemistry – A European Journal, EarlyView.
Copper(II) forms three chiral and EPR‐active complexes with monensinate A in methanol. Beside the bis [CuL2] and mono [CuL]+ species, the new dinuclear construct [Cu2L]3+ exhibits an [ML]+‐type and a metal salt‐type copper(II) centers weakly bound to each other through counter ion(s) and thus, being magnetically independent.
Máté Levente Kis   +7 more
wiley   +1 more source

reversed (radiochemical) isotope dilution analysis

open access: yes, 2014
Citation: 'reversed (radiochemical) isotope dilution analysis' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.R05375 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for ...
openaire   +1 more source

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