Results 41 to 50 of about 5,283 (209)

Atrial fibrillation, sinoatrial and atrioventricular node dysfunction in a mouse model of heart failure with preserved ejection fraction

Experimental Physiology, EarlyView.
Summary of the timeline of characterized events related to atrial fibrilation (AF) and diastolic dysfunction in a mouse heart failure with preserved ejection fraction (HFpEF) model. Three weeks after the initiation of the diet regimen with high fat diet (HFD) and Nω‐nitro‐l‐arginine methyl ester (l‐NAME) in drinking water to induce HFpEF, significantly
Bernadin Ndongson‐Dongmo, Reinhard Bauer, Finn Olav Levy   +2 more
wiley   +1 more source

Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy

Experimental Physiology, EarlyView.
Abstract Attenuation of sympathetic vasoconstriction during exercise (functional sympatholysis) contributes to skeletal muscle oxygen delivery–utilization matching. However, the extent to which muscle contractions impact noradrenergic regulation of interstitial oxygen pressures (PO2is${P_{{{\mathrm{O}}_2}}}_{{\mathrm{is}}}$; the driving force for blood–
Edward T. N. Calvo, Jacob M. Pontorno, Benjamin Zeidler, Taciane M. M. Pejon, Michael D. Belbis, Scott K. Ferguson, Craig J. Goergen, Timothy P. Gavin, Bruno T. Roseguini, Igor A. Fernandes, Daniel M. Hirai   +10 more
wiley   +1 more source

Intracardiac Shunts and Role of Tissue Doppler Imaging in Diagnosis and Discrimination [PDF]

Journal of Tehran University Heart Center, 2008
Background: We sought to assess right ventricular (RV) systolic and diastolic functions via tissue Doppler imaging (TDI) in order to discriminate right-to-left (bidirectional) from left-to-right intracardiac shunts.
Mersedeh Karvandi, Mohammad Asadpour Piranfar, Arash Mohammadi Tofigh   +2 more
doaj   +2 more sources

Cardiopulmonary function in special operations forces compared to conventional infantry soldiers

Experimental Physiology, EarlyView.
Abstract Fitness is essential to military personnel in general, especially in the special operations forces (SOF), where the demanding tasks require a high level of physical fitness and mental robustness. However, little research has been done on SOF to characterise the putative underlying cardiopulmonary adaptations that distinguish them from ...
Rasmus Syberg Rasmussen, Jakob Solgaard Jensen, Iben Elmerdahl Rasmussen, Jacob Peter Hartmann, Clara Sofie Egeberg, Anna Agnes Lytzen, Klara Nielsen, Malte Lund Adamsen, Mads Fischer, Ronan M. G. Berg   +9 more
wiley   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

The dependence of the time constant of left ventricular isovolumic relaxation (tau) on pericardial pressure. [PDF]

Circulation, 1990
The purpose of this study was to investigate the dependence of tau, the time constant of left ventricular (LV) isovolumic relaxation, on pericardial pressure and to compare values of tau as determined by the methods of previous investigators and by a standard exponential curve fit.
M A, Frais, D W, Bergman, I, Kingma, O A, Smiseth, E R, Smith, J V, Tyberg   +5 more
openaire   +2 more sources

Determining Preclinical Safety of Aclarubicin in Pediatric Malignancies

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background Anthracyclines are among the most effective chemotherapeutic agents used to treat pediatric malignancies. However, their clinical use is limited by dose‐dependent toxicities, particularly cardiotoxicity and secondary malignancies.
Darleen S. Tu, Aaron K. Olson, Kimberly S. Waggie, Nicolas M. Garcia, Virginia J. Hoglund, Stephanie I. Walter, Jenna R. Rosinski, Harini Sadeeshkumar, Radhika Patel, Erolcan Sayar, Michael C. Haffner, Lisa Maves, Jacques Neefjes, Jay F. Sarthy, Elizabeth R. Lawlor, Shireen S. Ganapathi   +15 more
wiley   +1 more source

Ivabradine Preserves Cardiac Structure and Reduces Cell Death in Four Dogs With Preclinical Mitral Valve Disease

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Reduces cardiac remodelling and apoptosis in dogs with MMVD stage B2: Long‐term treatment with ivabradine in dogs with asymptomatic myxomatous mitral valve disease (MMVD) stage B2 reduced heart rate without impairing cardiac function. ABSTRACT Background Ivabradine, a specific funny channel blocker, has shown cardiovascular benefits in humans and ...
Prapawadee Pirintr, Vudhiporn Limprasutr, Anudep Rungsipipat, Kasem Rattanapinyopituk, Suwanakiet Sawangkoon, Nakkawee Saengklub, Anusak Kijtawornrat   +6 more
wiley   +1 more source

Echocardiographic assessment of left and right ventricular diastolic functions in children with dilated cardiomyopathy

The Turkish Journal of Pediatrics, 1998
We evaluated left and right ventricular diastolic functions by pulsed Doppler echocardiography in 16 children with dilated cardiomyopathy and in 20 healthy age-matched control subjects.
F Alehan, S Ozkutlu, D Alehan, M Saraçlar   +3 more
doaj  

Collagen XV preserves heart function and protects from pathological remodelling after myocardial infarction

The FEBS Journal, Volume 293, Issue 2, Page 418-442, January 2026.
We analysed collagen XV expression in myocardial infarct samples and assessed how its deficiency affects cardiac responses, such as fibrogenesis and tissue stiffness. In mice, damage caused by myocardial infarction is exacerbated in the absence of collagen XV and leads to pathological remodelling and more severe left ventricle dysfunction (left panel ...
Sanna‐Maria Karppinen, Miki Aho, Zoltan Szabo, Johanna Magga, Laura Vainio, Erhe Gao, Paul Janmey, Lauri Eklund, Karolina Rasi, Ilkka Miinalainen, Lynn Y. Sakai, Lasse Pakanen, Heikki Huikuri, Juhani Junttila, Risto Kerkelä, Taina Pihlajaniemi   +15 more
wiley   +1 more source