Results 51 to 60 of about 6,514,201 (256)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Understanding the Meaning of Fatigue at the End of Life: An Ethnoscience Approach [PDF]
, 2013 Purpose: Fatigue is a devastating state of body and mind associated with distress at the end of life. We report the results of the third in a series of papers outlining a novel approach we have developed for understanding the meaning of fatigue by ...
Kirshbaum, Marilyn +5 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Scaling Invariance of Fatigue Crack Growth in Gigacycle Loading Regime [PDF]
, 2010 The role of the collective behavior of defect ensembles at the crack tip and the laws of fatigue crack propagation in R4 high strength steel have been studied under conditions of symmetric tension–compression gigacycle loading at 20 kHz.
O. Naimark +10 more
core +1 more source
Fracture and Structural Integrity, 2023 S-N curve fatigue samples of titanium alloy welded joints have such a comparatively significant scatter, that results in the issue that the fatigue life prediction accuracy is not optimal.
Yangjinyu Li, Li Zou, Zhengjie Zhu
doaj
Evaluation of Structural Behavior and Fatigue Performance of a KR-Type Rail Clip
Applied Sciences, 2021 Rail clips are essential components of rail fastening systems that clamp the rails to sleepers. Fatigue damage of rail clips has been recently reported in railway lines. However, there has been a lack of research investigating this fatigue issue.
Sang-Hyeok Kim +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
MODELLING OF STRESS GRADIENT EFFECT ON FATIGUE LIFE USING WEIBULL BASED DISTRIBUTION FUNCTION [PDF]
, 2013 In the present paper, a new approach is developed in order to take into account the stress gradient effect on fatigue life of structural components. The proposed approach is based on the weakest link concept in which the shape coefficient of the Weibull ...
PALIN-LUC, Thierry +2 more
core
Guest editorial: fatigue design and material defects [PDF]
, 2015 This issue of Fatigue and Fracture of Engineering Materials and Structures contains a collection of manuscripts presented at the Second International Symposium on Fatigue Design and Material Defects (FDMD II) held in Paris, France, on June 11 – 13, 2014 ...
Brüne, M +5 more
core +1 more source
Damage evaluation under complex fatigue loading conditions
Fracture and Structural Integrity, 2019 Fatigue damage and life assessment of multiaxial loadings is still an issue yet to resolve. Many methods have been proposed with promising agreements with the experimental results.
Luis Reis +5 more
doaj +3 more sources