Results 51 to 60 of about 40,017,348 (283)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Professional Self-determination of Modern Teenagers: Problems and Solutions [PDF]
Психологическая наука и образование (2007. Online), 2014 Professional self-determination in adolescence for many years has been one of the hot topics of psychological theory and practice. Research in the field of personal and professional self-determination, career choice, continues to be a priority ...
Ilyina O.B.,
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Frontiers in PsychologyDealing with change and the resulting process of transition is challenging. In today’s workplace, where change and innovation are increasingly a fact of life, too many transitions end in failure, at a high cost to both people and organizations.
Sarah Snape
doaj +1 more source
Career choice and the strength of weak ties
Central Bank Review, 2017 This paper argues that the structure (i.e., size and composition) of the informal search network is a crucial determinant of the career decisions of young workers.
Semih Tümen
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Social Sciences and Humanities OpenA student’s choice of higher education institution has enduring consequences extending beyond academics, affecting career trajectories and economic outcomes.
Animesh Karn +2 more
doaj +1 more source
Career aspirations among specialty residents in France: a cross-sectional gender-based comparison
BMC Medical Education, 2021 Background Most studies evaluating career aspirations among gender are performed in Anglo-Saxon countries. Two recent French studies looked at the career choice of residents in obstetrics & gynecology.
A. Cathelain +8 more
doaj +1 more source