Results 61 to 70 of about 40,017,348 (283)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Law and Safety, 2018 The main approaches to constructing a conceptual model of professional orientation of the population regarding the choice of an investigator’s profession have been provided.
N. E. Miloradova
doaj +1 more source
Immersion in the Profession: Experience of Career Guidance Work at Medical University
Высшее образование в России, 2020 Higher medical education places high demands to the quality of applicants’ knowledge, assumes the awareness of their choice of future profession. As practice shows, often this choice is made by high school students at the level of momentary desires ...
P. V. Tkachenko +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2020 In the social-cognitive career theory (SCCT), Lent, Brown and Hackett (1994, 2002) postulate an influence on behaviour in the career choice process through self-efficacy. If relationships between self-efficacy and career choice activities as well as knowledge can be confirmed, this results in possibilities of educational intervention for practical ...
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Exploring MBA career success [PDF]
, 2006 Purpose – The purpose of this paper is to examine the meaning of career success in relation to the attainment of an MBA degree, for a group of experienced managers.
Hay, AJ, Hodgkinson, M
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Career choice factors of high school students [PDF]
, 2002 Plan BMany factors affect career choices of high school students. Identifying these factors would give parents, educators, and industry an idea as to where students place most of their trust in the career selection process.
Borchert, Michael
core