Results 51 to 60 of about 3,604,006 (311)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Polish Contribution to Software Engineering Research 1992–2021

open access: yesFoundations of Computing and Decision Sciences, 2023
Since the collapse of the Soviet Bloc, Polish researchers in the software engineering area made a large e ort to close the gap developed during the times of the Iron Curtain and the ensuing limited access to Western technology.
Szydłowska Justyna, Swacha Jakub
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

IoT Based Health Monitoring with Diet, Exercise and Calories recommendation Using Machine Learning

open access: yesHuman-Centric Intelligent Systems
With the increasing awareness of health and fitness, the demand for more efficient and personalized fitness solutions is on the rise. This research proposes an innovative system that integrates innovative technologies to streamline gym operations ...
Muhammad Hassaan Naveed   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

IT Management in Organization

open access: yes, 2011
The thesis deals with information technologies on different levels of management. The first chapter analyzes a strategy level and a function of strategic documents in the IT management analyzed.
Eischmann, Jiří
core   +1 more source

Business Models for NFC based mobile payments

open access: yesJournal of Business Models, 2015
Purpose: The purpose of the paper is to develop a business model framework for NFC based mobile payment solutions consisting of four mutually interdepended components: the value service, value network, value architecture, and value finance.
Johannes Sang Un Chae, Jonas Hedman
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Assessing the barriers to green supply chain adoption using fuzzy DEMATEL technique [PDF]

open access: yesمطالعات مدیریت کسب و کار هوشمند, 2017
In recent decades, in line with increasing environmental risks and related human concerns, the concept of green supply chain has been introduced as a modern approach to reduce the environmental impact of organizational products by researchers.
Masoumeh Amani   +2 more
doaj   +1 more source

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