Results 61 to 70 of about 2,055,235 (248)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
ComTech, 2011 Information Technology (IT) grows very rapidly and affects every aspect of business life to support competition with other companies that have the same field. PT. Matahari Putra Prima has implemented a computerized system as one of its business strategy
Hendra Hendra
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Analisis Dampak Penerapan IT Service Desk pada Bank XYZ
ComTech, 2010 The purpose of this study is to identify the determinants of IT operational performance related to IT Service Desk. And to determine the consideration of implementing IT Service Desk in the company business processes.
Ario Adi Prasetyo, Ford Lumban Gaol
doaj +1 more source
Network Representation Learning: From Traditional Feature Learning to Deep Learning
IEEE Access, 2020 Network representation learning (NRL) is an effective graph analytics technique and promotes users to deeply understand the hidden characteristics of graph data.
Ke Sun +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Service Model for the Service Configuration [PDF]
, 2013 Service is a concept difficult to define. It has been extensively used in different contexts. According with literature a service can be seeing: as an activity or as an output of a process.By service customization we mean the definition and adaptation of a service according to the customer’ requirements, when this customization process is carried out ...
Jose Angel Lakunza +2 more
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Hessische Blätter für VolksbildungInitiative Finanzielle Bildung: „Finanzielle Bildung für das Leben' Lena Heidemann Transferkonferenz Hessischer Weiterbildungspakt Christiane Ehses Nachruf.
Thumbi, Ndung'u +7 more
openaire +3 more sources