Results 261 to 270 of about 12,596,900 (345)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Answering Frequently Asked Questions about Submission and Peer Review at JACS Au. [PDF]

JACS Au
Jones CW, Goring PD.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evidence for Digital Mental Health Assessment Tools in the Post-COVID-19 Era: Protocol for a Systematic Review on Diagnostic Accuracy Across Age Groups.

JMIR Res Protoc
Babbitt K, Funnell EL, Martin-Key N, Barker E, Bahn S.   +4 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Identification of Sarcopenic Obesity by Fat-to-Muscle Ratio in Older Adults: A Cohort Study. [PDF]

J Cachexia Sarcopenia Muscle
Kakita D, Harada K, Kurita S, Morikawa M, Nishijima C, Fujii K, Shimada H, Arai H.   +7 more
europepmc   +1 more source

TEvarSim: A genome simulator for transposable element (TE) variants. [PDF]

PLoS Comput Biol
Miao J, Li D.
europepmc   +1 more source

Training the Digital Clinician by Evaluating Health Education and Curriculum Integration New Zealand Psychology and Psychiatry Programs: Mixed Methods Study.

JMIR Med Educ
Rawnsley C, Stasiak K.
europepmc   +1 more source