Results 61 to 70 of about 2,367,253 (312)

Il connettivo concessivo tuttavia e i suoi corrispettivi russi: un’analisi contrastiva corpus-based

open access: yesMediAzioni, 2023
From a semantic perspective the relation of concession can be defined as a specific type of contrast between two states of affairs, i.e. counterexpectative contrast, in which the conflict originates by the denial of an assumption, generated by the first ...
Filippo Pecorari, Erica Pinelli
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Geography in Italian Licei [PDF]

open access: yes, 2016
Following a rapid description of the evolution of the teaching of geography in Italian secondary schools from the Unification of Italy to the end of the nineteenth century, the article focusses on the latest change, brought about with the Gelmini ...
DE VECCHIS, Gino
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

[Review of] Fred L. Gardaphe, Italian Signs, American Streets: The Evolution of Italian American Narrative [PDF]

open access: yes, 1996
This indispensable interpretation of Italian American narrative literature can fruitfully be used in many ethnic and cultural programs. It is a study distinguished by familiarity with vernacular Italian American culture, as well as consciousness of the ...
Birnbaum, Lucia Chiavola
core   +1 more source

Preaspiration in Sienese Italian & Its Interaction with Stress in /VC:/ Sequences [PDF]

open access: yes, 2004
This paper reports some initial results from our investigation into effects of stress in /VC:/ sequences in Sienese Italian. Our spontaneous speech data show preaspiration in /VC:/ sequences, not previously reported for any variety of Italian.
Bel, Bernard   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Dissatisfied and Disenchanted: How Italians View European and National Politics? eupinions brief | February 2018 [PDF]

open access: yes, 2018
The outcome of the Italian elections remains uncertain. It seems to be a fight between three major political forces, Forza Italia, Lega Nord and the Five Star Movement, all of which score high on populist and Eurosceptic rhetoric. For many years, Italian
de Vries, Catherine, Hoffmann, Isabell
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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