Results 61 to 70 of about 1,142,338 (239)

L’insegnamento delle conferenze messicane: il giudice quale motore di trasformazione sociale [PDF]

open access: yesDemocrazia e Diritti Sociali
The paper concerns the contribution given by Calamandrei with the Mexican conferences to the transformative constitutionalism that spread in Latin America. In particular, it dwells on the role of the judge as an engine of social transformation.
Elena Bindi
doaj  

Italian ethnic community schools in Rio Grande do Sul: between the rural and urban milieu (1875 - 1914)

open access: yesActa Scientiarum. Education, 2014
Current paper is the partial result of a research, funded by CNPq, on the History of the Italian Ethnic Community Schools inBrazil (1875-1945). Investigating and mapping school organizations established by Italian immigrants in the state ofRio Grande ...
Terciane Ângela Luchese   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Criteria and methods for the assessment of animal welfare - Presentation

open access: yesItalian Journal of Animal Science, 2010
With the constitution of the Commission “Criteria and methods for the assessment of animal welfare,” the Scientific Association of Animal Production (ASPA) intended to underscore the importance of a subject matter that qualifies animal ...
Pierlorenzo Secchiari
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

40 Years after the First Agreement. Assessments, Perspectives, Critical Issues, Rome, Sala della Regina, Montecitorio Palace, 19 February 2025

open access: yesStudia z Prawa Wyznaniowego
This report summarises the proceedings of the conference “40 years after the first agreement. Assessments, perspectives, critical issues”, organised in Rome (Sala della Regina, Montecitorio Palace) on 19 February 2025 by the Federation of Evangelical ...
Davide Dimodugno
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

La mediazione de iure condendo / La médiation de jure condendo / Mediation de iure condendo [PDF]

open access: yesRivista di Criminologia, Vittimologia e Sicurezza, 2013
Nel contributo si analizza criticamente l’opportunità di inserire ipotesi di mediazione penale nel nostro sistema processuale. In particolare, dopo aver esemplificato alcuni casi espletati in Inghilterra, si esamina la restorative justice sotto il ...
Tugnoli Francesca
doaj  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

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