Results 51 to 60 of about 4,510,000 (357)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Regions, Innovation Systems, and the North-South Divide in Italy [PDF]

, 2018
Using firm-level data collected by Statistics Italy for 2008, 2011, and 2015, we examine the Triple-Helix synergy among geographical and size distributions of firms, and the NACE codes attributed to these firms, at the different levels of regional and ...
Cucco, Ivan, Leydesdorff, Loet
core   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Variation in the prevalence of enteropathogenic Yersinia in slaughter pigs from Belgium, Italy, and Spain [PDF]

, 2011
Tonsils of 829 fattening pigs originating from Belgium (n = 201), Italy (n = 428), and Spain (n 200) were collected between 2005 and 2007 to study the prevalence of enteropathogenic Yersinia in slaughter pigs.
Fredriksson-Ahomaa, Maria, Houf, Kurt, Korkeala, Hannu, Martinez, Pilar Ortiz, Pallotti, Adolfo, Rosmini, Roberto   +5 more
core   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Utility of serological screening for measles, mumps and rubella in immunocompromised patients

Human Vaccines & Immunotherapeutics, 2019
Marchi et al. in their article (Measles in pregnancy: a threat for Italian women? Hum Vaccin Immunother. 2019 Jun 20:1–3) observed that 96.9% of pregnant women were positive for anti-measles IgG (with a higher risk of contracting measles in those aged 19–
L Sticchi, M. Astengo, I.G. Iavarone, G. Icardi   +3 more
doaj   +1 more source

Challenges of Interference and Disinformation in Italy: Countering New Threats to National Security [PDF]

Современная Европа
The focus of this article is the phenomenon of disinformation and foreign interference in Italy. The aim of the study is to examine Italy's approach to countering interference and combating disinformation.
Elena A. Maslova
doaj   +1 more source

A survey on feasibility of telehealth services among young Italian pharmacists

Pharmacy Practice, 2020
Background: Telemedicine is defined as “the use of medical information exchanged from one site to another via electronic communications to improve a patient’s health status”.
Simone Baldoni , Graziano Pallotta, Enea Traini, Getu G. Sagaro , Giulio Nittari , Francesco Amenta   +5 more
doaj   +1 more source

An overview of the EXTraS project: Exploring the X-ray Transient and Variable Sky

, 2015
The EXTraS project (Exploring the X-ray Transient and variable Sky) will harvest the hitherto unexplored temporal domain information buried in the serendipitous data collected by the European Photon Imaging Camera (EPIC) instrument onboard the ESA XMM ...
D'Agostino, D., De Luca, A., Haberl, F., Salvaterra, R., Tiengo, A., Watson, M. G., Wilms, J.   +6 more
core   +1 more source