Results 61 to 70 of about 2,397,266 (252)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
, 2003 People feeding birds in front of canal in Venice, Italy with bell towers and churches in background.Tiff file: 2990x4030 pixels, 34.5 Mb; Display: jpeg, 594x800 pixels ...
Father Edward Catich
core +1 more source
Shaping the Living Body: paradigms of soma and authority in Thomas Hanna’s writings
Revista Brasileira de Estudos da Presença, 2014 This article outlines some features of the discursive strategies adopted by Thomas Hanna in order to legitimate Somatics – as well as his own method – in the eyes of the scientific community.
Margherita De Giorgi (Università di Bologna, Bolonha, Italy)
doaj
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Italy-2018: The Triumph of Populism and Prospects of Exit from the Political Crisis
Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2019 Introduction. The article is devoted to the origins, grounds and possible consequences of the political crisis in modern Italy. The paper shows that the Italian crisis has acquired a scale that challenges the interests of political establishment of the ...
Sergey V. Biryukov +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
[Europe/Italy Watercolors BOH 1532]
, 2005 A waterway, with two boats (gondola), passes under a bridge and past a city street. Venice, Italy. Brush strokes along bottom edge.Tiff file: 1547 x 2224 pixels, 9.86 Mb; Display: jpeg, 556 x 800 pixels ...
Father Edward Catich
core +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
NHS commissioning practice and health system governance: a mixed-methods realistic evaluation
Health Services and Delivery Research, 2015 Background: By 2010 English health policy-makers had concluded that the main NHS commissioners [primary care trusts (PCTs)] did not sufficiently control provider costs and performance.
Rod Sheaff +8 more
doaj +1 more source