Results 101 to 110 of about 77,640 (305)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Anal itching [PDF]

BMJ, 2016
Sahnan, K, Lever, L, Philips, RKS
openaire   +6 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Verbal expressions describing itch quality in atopic dermatitis and urticaria: an online questionnaire survey in Japan

Journal of Cutaneous Immunology and Allergy
Background: The nature of itch sensation varies depending upon the patient and the disease. However, few studies have focused on verbal expressions describing itch of atopic dermatitis (AD) in quality.Objectives: To investigate itch quality in patients ...
Yukihiro Ohya, Toshiya Ebata, Yusei Ohshima, Tsugunobu Andoh, Mitsutoshi Tominaga, Yoko Kataoka, Yoshinori Fukui, Nobuyuki Ebihara, Shunji Hasegawa, Shigetoshi Kobayashi, Yutaka Morisawa, Norihiro Inoue, Masami Narita, Sakae Kaneko, Ken Igawa, Takeshi Nakahara, Yozo Ishiuji, Takaharu Okada, Masanori Fujii, Hiroshi Kawasaki, Hiroyuki Irie, Miho Shiratori-Hayashi, Hiroyuki Murota   +22 more
doaj   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

A protracted, postherpetic neuralgic ulcer treated with risperidone and intranasal butorphanol

JAAD Case Reports, 2021
Giuseppe Ingrasci, BS, Michael Arbrouk, MD, Karyn Haitz, MD, Robert Kirsner, MD, PhD, Gil Yosipovitch, MD   +4 more
doaj   +1 more source

The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats

Brain Research Bulletin
Direct and indirect evidence suggests that the prelimbic cortex (PrL) and the ventral tegmental area (VTA) are the key brain regions involved in the regulation of itch sensation and itch-related emotions.
Xing-Yu Lu, Jun-Fei Teng, Juan Yao, Xuan Li, Bing Wu, Xue-Qiang Hu, Ping Wang, Xiao-Qian Jiang, Jian-Feng Sui, Ke-Hui Hu, Yue-Ming Xu, Shu-Lei Liu   +11 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Itch Matrixes [PDF]

Frontiers in Medicine, 2021
Peyman Najafi, Peyman Najafi, Laurent Misery, Laurent Misery, Jean-Luc Carré, Douraied Ben Salem, Douraied Ben Salem, Olivier Dufor, Olivier Dufor   +8 more
openaire   +5 more sources

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source