Results 251 to 260 of about 39,357 (305)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Effects of Psychological Interventions on Itch, Scratching, and Excoriations: A Systematic Review and Meta-analysis. [PDF]

Acta Derm Venereol
Schut C, Munz J, Maas Genannt Bermpohl F, Van Laarhoven AIM, Schmidt J, Evers AWM, Kupfer J.   +6 more
europepmc   +1 more source

Dupilumab Improves Daily Symptom Burden in Adult Patients with Prurigo Nodularis: Post Hoc Analysis from LIBERTY PN-PRIME and PRIME2 Studies. [PDF]

Dermatol Ther (Heidelb)
Kwatra SG, Ständer S, Kim BS, Msihid J, Bansal A, Makhija M, Wiggins S, Zahn J, Thomas RB, Bahloul D.   +9 more
europepmc   +1 more source

Bridging the Gap in Chronic Prurigo Care: Evidence-Based Diagnostic and Therapeutic Recommendations from a Delphi Consensus Panel. [PDF]

Dermatol Ther (Heidelb)
Mendes-Bastos P, Lobo I, Pires da Rosa G, Pimenta R, Gonçalo M, Delphi panel.   +5 more
europepmc   +1 more source

Rapid Onset of Response in Adults with Dermatomyositis Receiving Dazukibart: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study. [PDF]

Clin Cosmet Investig Dermatol
Aggarwal R, Peeva E, Fiorentino DF, Vleugels RA, Mangold AR, Werth VP, Oemar BS, Rath JN, Sloan A, Chu M.   +9 more
europepmc   +1 more source

Gut microbiota and the kidney-gut-skin axis in chronic kidney disease-associated pruritus: mechanisms and therapeutic implications. [PDF]

Front Cell Infect Microbiol
Chen S, Liu J, Ni H, Zhu F, Liu H, Lin R.   +5 more
europepmc   +1 more source

Patient-reported Itch Outcome Measures for Chronic Pruritus in Dystrophic Epidermolysis Bullosa: Exploratory Analysis of a Phase 2 Randomized Controlled Trial. [PDF]

Acta Derm Venereol
Okata-Karigane U, Gorell ES, Pathmarajah P, Li S, Chiou AS.   +4 more
europepmc   +1 more source

Evaluation of Outcomes of Dupilumab Therapy in Patients with Atopic Dermatitis - A Single-Center Retrospective Longitudinal Study.

Indian J Dermatol
Miniello A, Pugliese F, Pepe I, Pastore G, Lassandro M, Calabrese C, Nettis E.   +6 more
europepmc   +1 more source

Itch

Lancet, The, 2003
Itch is a common skin sensation, with substantial effects on behaviour. Neurophysiological research has permitted accurate definition of neural pathways of itch, and has confirmed the distinctiveness of itch pathways in comparison with pain.
, Malcolm W Greaves, Martin Schmelz
exaly   +4 more sources

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Itch

Current Biology
A camping trip will quickly become unpleasant if a horde of mosquitoes descends while you pitch your tent, or you find yourself in a patch of poison oak. Whether due to an insect bite, a poisonous plant, or a chronic skin disease, everyone has experienced the urgent sensation of itch and the sweet relief of scratching.
Lillian N, Murphy, Ellen A, Lumpkin, Diana M, Bautista   +2 more
openaire   +2 more sources