Results 201 to 210 of about 25,829,571 (300)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

iHOT-12 item analysis: correlations between individual items and overall score within and across time points. [PDF]

J Hip Preserv Surg
Yuro M, Martin R, Wolff AB, Nho S, Wuerz T, Thiel GV, Christoforetti J, Salvo JP, Matsuda D, Carreira DS.   +9 more
europepmc   +1 more source

Psychometric evaluation of the Interpersonal Needs Questionnaire (INQ) using item analysis according to the Rasch model. [PDF]

PLoS One, 2020
Upegui-Arango LD, Forkmann T, Nielsen T, Hallensleben N, Glaesmer H, Spangenberg L, Teismann T, Juckel G, Boecker M.   +8 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Artificial Intelligence Meets Item Analysis (AI meets IA): A Study of Chatbot Training and Performance in detecting and correcting MCQ Flaws. [PDF]

Pak J Med Sci
Sabqat M, Khan RA, Jawaid M, Sajjad M.
europepmc   +1 more source

Impostorism in third-year medical students: an item analysis using the Clance impostor phenomenon scale. [PDF]

Perspect Med Educ, 2020
Levant B, Villwock JA, Manzardo AM.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Effective use of Item Analysis to improve the Reliability and Validity of Undergraduate Medical Examinations: Evaluating the same exam over many years: a different approach. [PDF]

Pak J Med Sci
Zubairi NA, AlAhmadi TS, Ibrahim MH, Hegazi MA, Gadi FU.   +4 more
europepmc   +1 more source

Why are some cases not on track? An item analysis of the Assessment for Signal Cases during inpatient psychotherapy. [PDF]

Clin Psychol Psychother, 2020
Probst T, Kleinstäuber M, Lambert MJ, Tritt K, Pieh C, Loew TH, Dahlbender RW, Delgadillo J.   +7 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source