Results 81 to 90 of about 27,060,511 (289)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Recent advances in analysis of differential item functioning in health research using the Rasch model

open access: yesHealth and Quality of Life Outcomes, 2017
BackgroundRasch analysis with a focus on Differential Item Functioning (DIF) is increasingly used for examination of psychometric properties of health outcome measures.
C. Hagquist, D. Andrich
semanticscholar   +1 more source

Penggunaan Rasch Model dalam Menganalisis Butir Soal Matematika Kelas V Sekolah Dasar

open access: yesIndonesian Journal of Islamic Elementary Education
Penelitian ini dilakukan untuk menganalisa butir soal yang digunakan untuk mengukur kesesuaian butir soal dan tingkat kesukaran soal pada peserta didik kelas V mata pelajaran matematika di Sekolah Dasar Swasta Pekalongan.
Debbi Silvia Aqida
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Tepatkah Nijmeegse Schoolbekwaamheids test (NST) untuk mengukur kesiapan sekolah siswa sekolah dasar awal pada konteks Indonesia? (Analisis empirik berdasar teori tes klasik)

open access: yesJurnal Ilmiah Psikologi Terapan, 2016
Nijmeegse Schoolbekwaamheids Test (NST) was a test to measure the readiness of children attend primary school. This research was a descriptive study that aims to determine the quality of the NST was empirically based on classical test theory as an ...
Lely Ika Mariyati   +1 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Construção de uma tarefa de leitura em voz alta de palavras: análise psicométrica dos itens The construction of a word reading aloud task: a psychometric item analysis report

open access: yesPsicologia: Reflexão e Crítica, 2012
O estudo descreve a análise dos itens que irão compor uma tarefa de leitura em voz alta de palavras isoladas. Um grupo de crianças do 2º ao 5º ano do Ensino Fundamental leu, por meio de microcomputadores, uma lista contendo 323 palavras de baixa ...
Patrícia Silva Lúcio   +3 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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