Results 171 to 180 of about 3,275,659 (305)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Design and psychometric properties of an instrument to evaluate nursing students' perceptions of discrimination by nurse educators: a protocol for a mixed-method study. [PDF]

BMJ Open
Yaghobi M, Ahmadi F, Mohammad Khan Kermanshahi S, Kazemnejad A, Vaismoradi M.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Designer Spotlight: Cristóbal Balenciaga

The Museum at FIT presents its Designer Spotlight series where MFIT curators explore objects in our permanent collection that highlight a specific designer's work and contributions to fashion.Born in Spain, Cristobal Balenciaga (1895-1972) opened his ...

core  

Psychometric Evaluation of the Turkish Mind Excessively Wandering Scale in Adolescents With ADHD: Exploratory Findings on Age-Related Differences in Excessive Mind Wandering. [PDF]

Int J Dev Neurosci
Güler HA, Bozkur B, Akbulut ÜH, Tezcan ME, Kandeğer A.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

FIT Entrepreneurship Series: Douglas Hand and Monica Phromsavanh

The FIT Foundation welcomes Douglas Hand and Monica Phromsavanh of Equal Hands in a virtual conversation hosted by Fern Mallis.Founded by Monica Phromsavanh, Equal Hands is a certified B-corp pending, fashion-forward lifestyle brand and retailer that is ...

core  

Development of a spatial skills test for 4th grade primary school students: validity and reliability study. [PDF]

Front Psychol
Aydın-Çolak E, Şahin N, Kıroğlu MK.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Psychological Landscape of Eating Disorders: A Study of Self-Control, Mood, and Personality Traits in Adults. [PDF]

Int J Methods Psychiatr Res
Deniz ME, Arslan Ü, Erdinç B, Shalqini V, Satıcı SA.   +4 more
europepmc   +1 more source