Results 161 to 170 of about 3,275,659 (305)
Designer Spotlight: Martin Margiela
The Museum at FIT presents its Designer Spotlight series where MFIT curators explore objects from our permanent collection that highlight a specific designer's work and their contributions to fashion.
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Limited Information Goodness-Of-Fit Testing In Multidimensional Contingency Tables [PDF]
We introduce a family of goodness-of-fit statistics for testing composite null hypotheses in multidimensional contingency tables of arbitrary dimensions. These statistics are quadratic forms in marginal residuals up to order r.
ALBERTO MAYDEU
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Designer Spotlight: Mariano Fortuny
The Museum at FIT presents its Designer Spotlight series where MFIT curators explore objects from our permanent collection that highlight a specific designer's work and their contributions to fashion.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Designer Spotlight: Stephen Burrows
The Museum at FIT presents its Designer Spotlight series where MFIT curators explore objects from our permanent collection that highlight a specific designer's work and their contributions to fashion. In this video narrated by Assistant Curator Elizabeth
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Accessories 1800-1900: Part One
The Museum at FIT presents “Accessories 1800–1900,” part one of a two-part introduction to the history of Western women’s fashion accessories. These two videos provide an historical overview for high school students interested in enrolling in FIT's ...
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