Results 61 to 70 of about 17,370,281 (337)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
SPECIFYING OPTIMUM EXAMINEES FOR ITEM PARAMETER ESTIMATION IN ITEM RESPONSE THEORY [PDF]
ETS Research Report Series, 1988 ABSTRACTInformation functions are used to find the optimum ability levels and maximum contributions to information for estimating item parameters in three commonly used logistic item response models. For the three and two parameter logistic models, examinees who contribute maximally to the estimation of item difficulty contribute little to the ...
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An-Najah University Journal for Research - B (Humanities), 2022 The study aims to reveal the effect of test items orderin estimating persons and items parameters using the five parameter logistic model, using the descriptive survey methodology. The study population consisted of all secondary students in the scientific stream in Ein Albash district, approximately their number (1940) male and female students.
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Assessing parameter invariance in item response theory’s logistic two item parameter model: A monte carlo investigation [PDF]
Tutorials in Quantitative Methods for Psychology, 2010 Statistical properties of the ability level estimate (theta) in item response theory (IRT) were investigated through a Monte Carlo investigation, based on data generated with a four cases multifactor design. Dichotomous items and the logistic two-parameter IRT model in a one-dimensional setting have been chosen.
Louis Laurencelle, Marlène Galdin
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The consequences of ignoring measurement invariance for path coefficients in structural equation models [PDF]
, 2014 We report a Monte Carlo study examining the effects of two strategies for handling measurement non-invariance – modeling and ignoring non-invariant items – on structural regression coefficients between latent variables measured with item response theory ...
Guenole, Nigel +3 more
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
ITEM‐ITEM CURVES AND CONSISTENT MENTAL TEST PARAMETER ESTIMATES1 [PDF]
ETS Research Bulletin Series, 1976 ABSTRACTIt is shown that empirical mental test P ‐ P plots are approximately‐equal to theoretical item‐item curves, at least for long tests administered to many people. This result is important because it leads to (1) a distribution free method for estimating points on item‐item curves, (2) a general method for defining estimates of item parameters and
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