Results 71 to 80 of about 17,370,281 (337)
The Estimates Item Parameter for Multidimensional Three-Parameter Logistics
KnE Social Sciences, 2020 The purpose of this study is to measure the accuracy of item parameters and abilities by using the Multidimensional Three-Parameter Logistics (M3PL) model. M3PL is a series of tests that measure more than one dimension of ability (θ). Item parameter estimation and the ability to model M3PL are reviewed based on a sample size of 1000 and test lengths of
Ode Zulaeha +2 more
openaire +2 more sources
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Pairwise Likelihood Estimation of the 2PL Model with Locally Dependent Item Responses
Applied SciencesThe local independence assumption is crucial for the consistent estimation of item parameters in item response theory models. This article explores a pairwise likelihood estimation approach for the two-parameter logistic (2PL) model that treats the local
Alexander Robitzsch
doaj +1 more source
mirt: A Multidimensional Item Response Theory Package for the R Environment
, 2012 Item response theory (IRT) is widely used in assessment and evaluation research to explain how participants respond to item level stimuli. Several R packages can be used to estimate the parameters in various IRT models, the most flexible being the ltm ...
R. P. Chalmers
semanticscholar +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Frontiers in Psychology, 2018 In joint models for item response times (RTs) and response accuracy (RA), local item dependence is composed of local RA dependence and local RT dependence. The two components are usually caused by the same common stimulus and emerge as pairs.
Peida Zhan, Manqian Liao, Yufang Bian
doaj +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Item-saving assessment of self-care performance in children with developmental disabilities: A prospective caregiver-report computerized adaptive test. [PDF]
PLoS ONE, 2018 The purpose of this study was to construct a computerized adaptive test (CAT) for measuring self-care performance (the CAT-SC) in children with developmental disabilities (DD) aged from 6 months to 12 years in a content-inclusive, precise, and efficient ...
Cheng-Te Chen +5 more
doaj +1 more source