Results 41 to 50 of about 21,370,789 (250)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Fractals of Interpolative Kannan Mappings

Fractal and Fractional
In 2018, Erdal Karapinar introduced the concept of interpolative Kannan operators, a novel adaptation of the Kannan mapping originally defined in 1969 by Kannan. This new mapping condition is more lenient than the basic contraction condition.
Xiangting Shi, Umar Ishtiaq, Muhammad Din, Mohammad Akram   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Global Structure of Iterated Function Systems [PDF]

, 2009
I study sets of attractors and non-attractors of finite iterated function systems. I provide examples of compact sets which are attractors of iterated function systems as well as compact sets which are not attractors of any iterated function system.
Snyder, Jason Edward
core   +1 more source

On Product Neutrosophic Fractal Spaces and α-Density Theory with Arbitrarily Small and Controlled Error

Fractal and Fractional
In this manuscript, we present the classical Hutchinson–Barnsley theory on the product neutrosophic fractal spaces by utilizing an iterated function system, which is enclosed by neutrosophic Edelstein contractions and a finite number of neutrosophic b ...
Khaleel Ahmad, Umar Ishtiaq, Ghulam Murtaza, Ioan-Lucian Popa, Fethi Mohamed Maiz   +4 more
doaj   +1 more source

The Generalized Iterated Function System and Common Attractors of Generalized Hutchinson Operators in Dislocated Metric Spaces

Fractal and Fractional, 2023
In this paper, we present the generalized iterated function system for the construction of common fractals of generalized contractive mappings in the setup of dislocated metric spaces.
Talat Nazir, Sergei Silvestrov
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source