Results 61 to 70 of about 9,739,092 (302)

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Design of foundation rafts by uncoupled iterative method

open access: yesComputer Assisted Methods in Engineering and Science, 2023
The authors developed a calculation module into a commercial finite element analysis (FEA) program, which is capable of calculating foundation rafts quickly, with correct results for the engineering practice.
Árpád Tornyos, Zoltan Czap
doaj  

Near-capacity iterative decoding of binary self-concatenated codes using soft decision demapping and 3-D EXIT charts [PDF]

open access: yes, 2010
In this paper 3-D Extrinsic Information Transfer (EXIT) charts are used to design binary Self-Concatenated Convolutional Codes employing Iterative Decoding (SECCC-ID), exchanging extrinsic information with the soft-decision demapper to approach the ...
Butt, Muhammad Fasih   +3 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Improved Newton Iterative Algorithm for Fractal Art Graphic Design

open access: yesComplexity, 2020
Fractal art graphics are the product of the fusion of mathematics and art, relying on the computing power of a computer to iteratively calculate mathematical formulas and present the results in a graphical rendering. The selection of the initial value of
Huijuan Chen, Xintao Zheng
doaj   +1 more source

Introducing Experience Goals into Packaging Design [PDF]

open access: yes, 2016
Consumer experiences are an increasingly important driving force for commerce, affecting also packaging design. Yet, experience design for packages is rarely studied.
Roto, Virpi   +3 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Frequency domain iterative feedforward/feedback tuning for MIMO ANVC

open access: yes, 2007
A new iterative feedback/feed-forward tuning (IFFT) method is presented for multiple-input multiple-output (MIMO) control systems that relies on efficient computation of the negative gradient of the controller cost function in the frequency domain.
Veres, S.M., Luo, J.
core   +1 more source

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