Results 51 to 60 of about 1,234,902 (331)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Iterative methods for nonlinear quasi complementarity problems

International Journal of Mathematics and Mathematical Sciences, 1987
In this paper, we consider and study an iterative algorithm for finding the approximate solution of the nonlinear quasi complementarity problem of finding u ϵ k(u) such that Tu ϵ k*(u)  and  (u−m(u),Tu)=0 where m is a point-to-point mapping, T is a ...
Muhammad Aslam Noor
doaj   +1 more source

Preconditioned iterative methods for Navier-Stokes control problems [PDF]

, 2013
PDE-constrained optimization problems are a class of problems which have attracted much recent attention in scientific computing and applied science. In this paper, we discuss preconditioned iterative methods for a class of Navier-Stokes control problems,
Pearson, John W.
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

High-Order Iterative Methods for the DMP Inverse

Journal of Mathematics, 2018
We investigate two iterative methods for computing the DMP inverse. The necessary and sufficient conditions for convergence of our schemes are considered and the error estimate is also derived.
Xiaoji Liu, Naping Cai
doaj   +1 more source

Iterative strategies for solving linearized discrete mean field games systems

Networks and Heterogeneous Media, 2012
Mean fields games (MFG) describe the asymptotic behavior of stochastic differential games in which thenumber of players tends to $+\infty$. Under suitable assumptions,they lead to a new kind of system of two partial differential equations: a forward ...
Yves Achdou, Victor Perez
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Properties and Iterative Methods for the Q-Lasso

Abstract and Applied Analysis, 2013
We introduce the Q-lasso which generalizes the well-known lasso of Tibshirani (1996) with Q a closed convex subset of a Euclidean m-space for some integer m≥1.
Maryam A. Alghamdi, Mohammad Ali Alghamdi, Naseer Shahzad, Hong-Kun Xu   +3 more
doaj   +1 more source