Results 71 to 80 of about 296,284 (267)

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan   +46 more
wiley   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin   +12 more
wiley   +1 more source

On a computer implementation of the block Gauss-Seidel method for normal systems of equations

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2016
This article focuses on the modification of the block option Gauss-Seidel method for normal systems of equations, which is a sufficiently effective method of solving generally overdetermined, systems of linear algebraic equations of high dimensionality ...
Alexander I Bogdanova   +1 more
doaj   +1 more source

Iterative learning control for constrained linear systems [PDF]

open access: yes, 2009
This paper considers iterative learning control for linear systems with convex control input constraints. First, the constrained ILC problem is formulated in a novel successive projection framework.
Chu, B., Owens, D.H.
core  

Where, how, and how much? A multicenter cohort study of the relationship between lupus decision aid modality, place of administration, interruption and viewing completeness and patient‐reported outcomes

open access: yesArthritis Care &Research, Accepted Article.
Objective We assessed whether shared decision‐making (SDM), and patient acceptability, feasibility, and overall satisfaction with a computerized patient decision aid (PtDA) for patients with systemic lupus erythematosus (SLE), differs by PtDA setting, modality, and the viewing experience.
Jasvinder A. Singh   +3 more
wiley   +1 more source

Bernoulli Collocation Method for Solving Linear Multidimensional Diffusion and Wave Equations with Dirichlet Boundary Conditions

open access: yesAdvances in Mathematical Physics, 2017
A numerical approach is proposed for solving multidimensional parabolic diffusion and hyperbolic wave equations subject to the appropriate initial and boundary conditions. The considered numerical solutions of the these equations are considered as linear
Bashar Zogheib   +2 more
doaj   +1 more source

Development of a personalized visualization and analysis tool to improve clinical care in complex multisystem diseases with application to scleroderma

open access: yesArthritis Care &Research, Accepted Article.
Background In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of a scleroderma patient's ...
Ji Soo Kim   +18 more
wiley   +1 more source

A Bramble-Pasciak conjugate gradient method for discrete Stokes equations with random viscosity

open access: yes, 2018
We study the iterative solution of linear systems of equations arising from stochastic Galerkin finite element discretizations of saddle point problems. We focus on the Stokes model with random data parametrized by uniformly distributed random variables ...
Lang, Jens   +2 more
core   +1 more source

Lived and care experiences of chronic musculoskeletal shoulder pain in Australian adults: A qualitative study

open access: yesArthritis Care &Research, Accepted Article.
Objectives Australian evidence on lived and care experiences of chronic musculoskeletal shoulder pain (CMSP), irrespective of disorder classification or disease, is limited. However, such evidence is important for person‐centred care and informing local service pathways and care guidelines or standards.
Sonia Ranelli   +8 more
wiley   +1 more source

Study of methods for dimension reduction of complex dynamic linear systems models

open access: yesMATEC Web of Conferences, 2018
Complex dynamic linear systems of equations are solved by numerical iterative methods, which need much computation and are timeconsuming ones, and the optimization stage requires repeated solution of these equation systems that increases the time on ...
Manatskov Yuriy M.   +3 more
doaj   +1 more source

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