Results 51 to 60 of about 85,505,833 (256)
Low-Complexity Numerical Approach for the Diffusion Equation with Variable Diffusion Coefficient
MathematicsThe diffusion equation models a wide variety of physical and chemical processes and has significant interest in many scientific disciplines. Analytical and numerical methods found in the literature for solving the diffusion equation consider a constant ...
Marta Zárraga-Rodríguez +2 more
doaj +1 more source
Iterative methods for the force-based quasicontinuum approximation : analysis of a 1D model problem [PDF]
, 2011 Force-based atomistic-continuum hybrid methods are the only known pointwise consistent methods for coupling a general atomistic model to a finite-element continuum model.
Luskin, Mitchell Barry +7 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On Improving Computational Efficiency of Simplified Fluid Flow Models
Chemical Engineering Transactions, 2018 Single-core computational efficiency of several iterative methods for numerical solution of nonsymmetric linear systems originating from simplified fluid flow models is evaluated together with different preconditioning techniques in terms of solution ...
Vojtech Turek
doaj +1 more source
On Local Relaxation Methods and Their Application to Convection-Diffusion Equations [PDF]
, 1981 This paper discusses local relaxation (LR) methods which can be regarded as generalizations of the successive overrelaxation (SOR) method. The difference is that within an LR method the relaxation factor is allowed to vary from equation to equation.
Veldman, Arthur E.P., +3 more
core +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
An Efficient Sixth-Order Newton-Type Method for Solving Nonlinear Systems
Algorithms, 2017 In this paper, we present a new sixth-order iterative method for solving nonlinear systems and prove a local convergence result. The new method requires solving five linear systems per iteration.
Xiaofeng Wang, Yang Li
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source