Results 41 to 50 of about 85,505,833 (256)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
OpenFOAM iterative methods efficiency analysis for linear systems solving
Труды Института системного программирования РАН, 2018 Significant part of the computational work in numerical simulations of technical systems, physical phenomena and technological processes is solving of linear algebraic equations systems arising from the discretization of the corresponding differential or
I. K. Marchevsky, V. V. Puzikova
doaj
Technologies, 2018 Efficient full-chip thermal simulation is among the most challenging problems facing the EDA industry today, especially for modern 3D integrated circuits, due to the huge linear systems resulting from thermal modeling approaches that require unreasonably
George Floros +3 more
doaj +1 more source
The Faber polynomials for annular sectors and an application to the iterative solution of linear systems of equations [PDF]
, 1994 A conformal mapping of the exterior of the unit circle to the exterior of a region of the complex plane determines the Faber polynomials for that region.
Myers, Nicholas John, Myers, N.J
core
Fast interior point solution of quadratic programming problems arising from PDE-constrained optimization [PDF]
, 2017 Interior point methods provide an attractive class of approaches for solving linear, quadratic and nonlinear programming problems, due to their excellent efficiency and wide applicability.
Gondzio, Jacek +4 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
A generalized preconditioned MHSS method for a class of complex symmetric linear systems
Mathematical Modelling and Analysis, 2013 Based on the MHSS (Modified Hermitian and skew-Hermitian splitting) and preconditioned MHSS methods, we will present a generalized preconditioned MHSS method for solving a class of complex symmetric linear systems.
Mehdi Dehghan +2 more
doaj +1 more source
Numerical Solution Of System Of Linear Equations By Iterative Methods
, 2017 Numerical method is the important aspects in solving real world problems that are related to mathematics, science, medicine, business are very few examples. Numerical method is the area related to mathematics and computer science which create, analysis and implements algorithm to numerically solve the system of linear equations.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source