Results 41 to 50 of about 6,495 (256)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Sillages Critiques, 2015 In Kamila Shamsie's 2002 novel, the 1971 Pakistan civil war becomes the traumatic experience which is everyone's psychological benchmark, even for those not yet born -- the young protagonists wonder “Is it shame at losing the war, or guilt about what we ...
David Waterman
doaj +1 more source
Co-Existing in Differences: Tailoring Travel Itineraries for Tourists With Similar Interests
IEEE Access, 2023 Customized tourism is gaining more and more attention in the era of the prominent personalization of tourists. Private customization has disadvantages such as high cost and resource consumption.
Chao Yu, Mengli Yang
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
From Documentary to Fiction. The Picture of the Balkans in Early Slovak Literature [PDF]
Slovenska Literatura, 2018 The very first attempts at travel literature include accounts of the journeys made two Humanist scholars Pavol Rubigal and Ján Dernschwam, whose lives and activities were associated with Slovak mining towns.
Erika Brtáňová
doaj
Land, 2021 Tourism in natural areas attracts people seeking contact with pristine ecosystems as opposed to a polluted urban habitat and a stressful pace of life. An adequate tourist route and itinerary guarantees a high level of tourist satisfaction.
Alex Vinicio Gavilanes Montoya +6 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Newly-discovered traces of the Roman Naissus-Ratiaria road and the problem of locating two Timacum stations [PDF]
Balcanica, 2007 The goal of this paper is to reopen the question of and propose a solution to the as yet unresolved problem of the exact location of the Timacum stations on the Naissus-Ratiaria itinerary road. Based on plentiful material evidence it seeks to draw a more
Petrović Vladimir P. +1 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source