Results 241 to 250 of about 41,330 (277)
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Immune thrombocytopenia (ITP): Pathophysiology update and diagnostic dilemmas.
Veterinary clinical pathology, 2019Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. The understanding of ITP pathogenesis is rapidly evolving. We now recognize ITP as a complex and heterogeneous syndrome that results from a combination of humoral and cell-mediated ...
D. LeVine, M. Brooks
semanticscholar +1 more source
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2021
Helicobacter eradication therapy is the first-line therapy for patients with Helicobacter positive idiopathic thrombocytopenic purpura (ITP) in Japan. Indications for treatement in patients with Helicobacter negative, or post-Helicobacter eradicated ITP are platelet counts less than 20×106/l or severe bleeding.
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Helicobacter eradication therapy is the first-line therapy for patients with Helicobacter positive idiopathic thrombocytopenic purpura (ITP) in Japan. Indications for treatement in patients with Helicobacter negative, or post-Helicobacter eradicated ITP are platelet counts less than 20×106/l or severe bleeding.
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PD-1/PD-L Pathway Potentially Involved in ITP Immunopathogenesis
Thrombosis and Haemostasis, 2019The binding of programmed death 1 (PD-1) to its ligands PD-L1 and PD-L2 on antigen-presenting cells turns off autoreactive T cells and induces peripheral tolerance.
Mu Nie +11 more
semanticscholar +1 more source
Blood, 2013
![Figure][1] A 23-year-old primigravida woman presented with recurrent mucocutaneous bleeding since the age of 7 years. She was diagnosed with acute immune-mediated thrombocytopenia (ITP), and splenectomy was performed in 2006 after failure to respond to steroid therapy.
Bushra Moiz, Anila Rashid
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![Figure][1] A 23-year-old primigravida woman presented with recurrent mucocutaneous bleeding since the age of 7 years. She was diagnosed with acute immune-mediated thrombocytopenia (ITP), and splenectomy was performed in 2006 after failure to respond to steroid therapy.
Bushra Moiz, Anila Rashid
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International Journal of Eating Disorders, 2018
OBJECTIVE Family Therapy for Anorexia Nervosa (FT-AN) is the first line treatment for adolescents with anorexia nervosa in the UK. However, research suggests between 10 and 40% of young people have a poor outcome.
M. Simic +6 more
semanticscholar +1 more source
OBJECTIVE Family Therapy for Anorexia Nervosa (FT-AN) is the first line treatment for adolescents with anorexia nervosa in the UK. However, research suggests between 10 and 40% of young people have a poor outcome.
M. Simic +6 more
semanticscholar +1 more source
Blood, 2003
The question, “Doctor, is it safe for me to become pregnant?” is one of the more charged issues confronting a woman with idiopathic thrombocytopenic purpura (ITP) and her physician. Maternal platelet counts can fall during even uncomplicated pregnancies.
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The question, “Doctor, is it safe for me to become pregnant?” is one of the more charged issues confronting a woman with idiopathic thrombocytopenic purpura (ITP) and her physician. Maternal platelet counts can fall during even uncomplicated pregnancies.
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Blood, 2012
Just as we all have had our fill of the many articles on the T regulatory cell (Treg) abnormalities in immune thrombocytopenia (ITP), in this issue of Blood Li et al have identified a new regulatory player; the B regulatory cell (Breg).1 They find that Bregs have similar properties to Tregs in ITP; they are deficient in active disease and therapy that ...
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Just as we all have had our fill of the many articles on the T regulatory cell (Treg) abnormalities in immune thrombocytopenia (ITP), in this issue of Blood Li et al have identified a new regulatory player; the B regulatory cell (Breg).1 They find that Bregs have similar properties to Tregs in ITP; they are deficient in active disease and therapy that ...
openaire +3 more sources
Immune Thrombocytopenic Purpura ITP
Vox Sanguinis, 1998AbstractImmune thrombocytopenic purpura ITP is characterized by early platelet destruction due to an unbalanced immune response. In acute ITP, a transient increase of HLA‐DR molecules has been detected while in individuals with chronic ITP, in addition, increased serum concentrations of IL‐2 and other cytokines reflecting in vivo T‐cell activation have
Paul Imbach, Thomas Kühne
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2017
Antiplatelet autoantibodies play a critical role in autoimmune thrombocytopenia (ITP). Thus, characterization of autoantigens recognized by autoantibodies is a prerequisite for elucidating its pathophysiology. Platelet glycoprotein (GP) IIb-IIIa and/or GPIb-IX are the two major autoantigens in ITP.
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Antiplatelet autoantibodies play a critical role in autoimmune thrombocytopenia (ITP). Thus, characterization of autoantigens recognized by autoantibodies is a prerequisite for elucidating its pathophysiology. Platelet glycoprotein (GP) IIb-IIIa and/or GPIb-IX are the two major autoantigens in ITP.
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Multi-dysfunctional pathophysiology in ITP
Critical Reviews in Oncology/Hematology, 2005Idiopathic thrombocytopenic purpura (ITP) is an organ-specific autoimmune disorder characterized by a low platelet count and mucocutaneous bleeding. The decrease of platelets is caused by increased autoantibodies against self-antigens, particularly IgG antibodies against GPIIb/IIIa.
Hui Zhao +3 more
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