Results 31 to 40 of about 26,841 (202)

Pathogenesis-oriented approaches for the management of corticosteroid-resistant or relapsedprimary immune thrombocytopenia

open access: yesOpen Medicine, 2016
Primary immune thrombocytopenia (ITP) is a complex autoimmune disorder in which the patient’s immune system reacts with platelet autoantigens resulting in immune-mediated platelet destruction and/or suppression of platelet production. Corticosteroids can
Liu Xin-guang, Hou Ming
doaj   +1 more source

Circulating microRNAs in patients with immune thrombocytopenia before and after treatment with thrombopoietin-receptor agonists

open access: yesPlatelets, 2020
MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. Dysregulated expression of several miRNAs has been found in primary immune thrombocytopenia (ITP) suggesting that miRNAs are likely involved in the pathogenesis ...
Lamya Garabet   +9 more
doaj   +1 more source

A hospital based cross-sectional study on platelet parameters in adult patients with dengue, its serological subgroups, and controls

open access: yesPlatelets, 2022
Our objective was to analyze if there was a significant relationship between platelet parameters (PLT, MPV, PDW, P-LCR, PCT) among dengue, its serological subgroups and controls.
Antony Gnana Shahila M   +1 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A Perspective on Interactive Theorem Provers in Physics

open access: yesAdvanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Endothelial alterations in a canine model of immune thrombocytopenia

open access: yesPlatelets, 2019
Bleeding heterogeneity amongst patients with immune thrombocytopenia (ITP) is poorly understood. Platelets play a role in maintaining endothelial integrity, and variable thrombocytopenia-induced endothelial changes may influence bleeding severity ...
Dana N. LeVine   +14 more
doaj   +1 more source

Report of a ‘consensus’ on the lines of therapy for primary immune thrombocytopenia in adults, promoted by the Italian Gruppo di Studio delle Piastrine

open access: yesPlatelets, 2020
Despite the publication in 2009 of a paper on ‘terms and definitions of immune thrombocytopenia’ (ITP), some unresolved issues remain and are reflected by the disagreement in the treatment suggested for primary ITP in adults.
Lorenzo Cirasino   +12 more
doaj   +1 more source

PENGEMBANGAN KLINIK LITERASI BERBASIS PERMAINAN BAHASA DALAM KEGIATAN LITERASI DASAR PADA MASA PANDEMI COVID-19

open access: yesPaedagoria, 2021
Abstrak: Tujuan penelitian ini untuk (1) mendeskripsikan konsep pengembangan klinik literasi berbasis permainan bahasa; (2) mendeskripsikan efektivitas pengembangan klinik literasi berbasis permainan bahasa dalam kegiatan literasi dasar pada masa pandemi
I Nengah Sueca, Ida Ayu Dewi
doaj   +1 more source

Defining Features of Gabriele‐de Vries Syndrome in Adults: A Case Report and Literature Review

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gabriele‐de Vries syndrome (GADEVS) is a neurodevelopmental disorder caused by heterozygous pathogenic variants in the YY1 gene. Like most rare genetic syndromes, the adult manifestations of GADEVS remain poorly defined. Here, we describe the oldest patient reported to date with GADEVS—a 63‐year‐old woman with a c.1177_1179del YY1 variant ...
Ethan W. Hollingsworth, Changrui Xiao
wiley   +1 more source

Primary Immune Thrombocytopenia and Thrombopoietin Receptor Agonists: Feasibilities of Treatment Discontinuation upon Achieving Stable Complete Platelet Response

open access: yesКлиническая онкогематология, 2023
Aim. To assess the stability of clinical remission in patients with primary immune thrombocytopenia (ITP) after withdrawal of thrombopoietin receptor agonists (TPO-RAs). Materials & Methods.
O. Yu. Vinogradova   +6 more
doaj   +1 more source

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