Results 41 to 50 of about 26,841 (202)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Older Adults and Immune Thrombocytopenia: Considerations for the Clinician

Clinical Interventions in Aging, 2023
Etienne Crickx,1,2 Matthieu Mahévas,1,3,4 Marc Michel,1 Bertrand Godeau1 1Service de Médecine Interne, Centre national de référence des cytopénies auto-immunes de l’adulte, Hôpital Henri Mondor, Fédération Hospitalo-Universitaire TRUE InnovaTive theRapy ...
Crickx E, Mahévas M, Michel M, Godeau B
doaj  

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Idiopathic thrombocytopenic purpura (ITP) – new era for an old disease

Romanian Journal of Internal Medicine, 2019
Immune thrombocytopenia is an autoimmune hematological disorder characterized by severely decreased platelet count of peripheral cause: platelet destruction via antiplatelet antibodies which may also affect marrow megakaryocytes.
Onisâi Minodora, Vlădăreanu Ana-Maria, Spînu Andreea, Găman Mihaela, Bumbea Horia   +4 more
doaj   +1 more source

Reverse Engineering and Performance Evaluation of a Pump Impeller Fabricated With Additive Manufacturing

Chemie Ingenieur Technik, EarlyView.
This study explores the process chain for reverse engineering and additive manufacturing of a water pump impeller in a process plant. Key aspects include digital twin creation, CAD redesign, material certification, Hirtisation postprocessing, and performance testing. Insights highlight iterative design for improved precision and reliability.
Michael Stadler, Kati Schatz, Sebastian Rehfeldt, Harald Klein   +3 more
wiley   +1 more source

Idiopathic Thrombocytopenic Purpura and Cardiovascular Disease: Is Elevated Triglycerides to High-density Lipoprotein Cholesterol Ratio a Marker?

İstanbul Medical Journal, 2023
Introduction:Triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio is used as a cardiovascular risk marker. We aimed to investigate the relationship between TG/HDL ratio and eltrombopag use, current platelet values and whether or not ...
Arzu Cennet Işık, Esra Turan Erkek, Müjgan Kaya Tuna   +2 more
doaj   +1 more source

Learning to Be Kind to Me: A Compassion‐Focused Group for Adolescents With Anorexia Nervosa

European Eating Disorders Review, EarlyView.
ABSTRACT Background Anorexia nervosa (AN) is often characterised by high levels of shame and self‐criticism. Compassion‐Focused Therapy (CFT) is a transdiagnostic intervention targeting these emotional vulnerabilities, yet its application in adolescent eating disorder services remains underexplored.
Talia Drew, Pamela Fox, Charlotte Waton, Isobel Hyatt, Julian Baudinet   +4 more
wiley   +1 more source

Maternal and neonatal outcomes in Gaza amid armed hostilities in 2025

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study documents facility‐based maternal, obstetric, and neonatal outcomes and associated conflict‐related exposures and living conditions among pregnancy‐related encounters at Al‐Helou Maternity Hospital in Gaza from late April to early September 2025, with a small number of additional encounters recorded at Al‐Shifa Medical ...
Shaymaa Abuhaiba, Younis Elijla, Aya El‐Dadah, Othman Nassar, Meran Abu‐Sultan, Maysaa Almasry, Hebatallah Alkhatib, Mahmoud Alsady, Amir Mahdi Ghafarian, Muath Alsarafandi, Lina Abumughessib, Arham Ali, Yassar Arain, Abeerah Muhammad, Belal Aldabbour, Shayan Ali, Bilal Irfan   +16 more
wiley   +1 more source

Newly Diagnosed Primary Immune Thrombocytopenia in Children: Which Guideline to Adhere?

Scripta Score Scientific Medical Journal, 2021
Background: Immune thrombocytopenia purpura (ITP) is an autoimmune disorder of bleeding which is defined as having thrombocytopenia (platelet count below 100.000/µL).
Cipta Mahendra
doaj   +1 more source

ITP: Tolerance Lost [PDF]

Blood, 2011
Despite a seemingly unifying phenotype comprising a reduced platelet count and mucocutaneous bleeding in many newly identified cases, immune thrombocytopenia (ITP) is a disorder of diverse pathogenesis.
openaire   +2 more sources