Results 41 to 50 of about 35,748 (242)

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis

Biomolecules, 2021
Depression affects the reproductive axis at the hypothalamus and pituitary levels, which has a significant impact on female fertility. It has been reported that G protein-coupled receptor 1 (Gpr1) mRNA is expressed in both the hypothalamus and ovaries ...
Rongrong Li, Chiyuan Ma, Yue Xiong, Huashan Zhao, Yali Yang, Li Xue, Baobei Wang, Tianxia Xiao, Jie Chen, Xiaohua Lei, Baohua Ma, Jian Zhang   +11 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Modeling and Evaluation of a Dynamic Channel Selection Framework for Multi-Channel Operation in ITS-G5

Telecom, 2023
Many years ago, it seemed inconceivable that our cars could drive autonomously or communicate with each other to form a self-organizing convoy or platoon.
Ottó Váczi, László Bokor
doaj   +1 more source

Thermoplastic Dielectric Coatings for Flexible Electrodynamic Dust Shields: Structural and Functional Performance

Advanced Materials Interfaces, EarlyView.
Thermoplastic attachment is introduced as a scalable surface coating strategy to improve the durability and dielectric reliability of flexible electrodynamic dust shields. By embedding chemically modified reduced graphene oxide (CMrGO) electrodes within thermoplastic laminates, mechanical degradation, abrasion damage, and vacuum‐induced electrical ...
Ide E. Onal, Emily A. Ryan, Luca Scifoni, Thomas M. Orlando, Álvaro Romero‐Calvo, Julie S. Linsey, Meisha L. Shofner   +6 more
wiley   +1 more source

Effects of resveratrol-loaded dendrimer nanomedicine on hepatocellular carcinoma cells

Frontiers in Immunology
Resveratrol (Res), a Chinese herbal extract, has demonstrated a remarkable and distinct antitumor effect, characterized by prolonged efficacy and minimal adverse reactions.
Jiao Qu, Yueqin Zhang, Cong Song, Yue Wang   +3 more
doaj   +1 more source

Medical Nutrition Therapy Access in CKD: A Cross-sectional Survey of Patients and ProvidersPlain-Language Summary

Kidney Medicine, 2021
Rationale & Objective: Nutrition management can slow the progression of chronic kidney disease (CKD) and help manage complications of CKD, but few individuals with CKD receive medical nutrition therapy before initiating dialysis.
Elizabeth Yakes Jimenez, Kathryn Kelley, Marsha Schofield, Deborah Brommage, Alison Steiber, Jenica K. Abram, Holly Kramer   +6 more
doaj   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

The Emerging JEV Genotype 5 Exhibits Distinct Codon Usage Characteristics

Pathogens
This study investigates the codon usage characteristics of Japanese encephalitis virus (JEV) genotype 5 (G5). Based on 339 complete JEV genome sequences, we systematically compared the codon usage patterns of G5 with other genotypes (G1–G4) using a multi-
Xiaoyu Gu, Ruichen Wang, Yuhong Yang, Weijia Zhang, Qikai Yin, Kai Nie, Shihong Fu, Qianqian Cui, Fan Li, Huanyu Wang, Songtao Xu   +10 more
doaj   +1 more source

Glutaminolysis Blockade-Empowered Bimodal Nanodepot for Spatially Complementary Sono-Thermal Ablation via PANoptosis and STING Activation Against Large Tumors. [PDF]

Adv Sci (Weinh)
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Liu YM, Qin J, Wu SY, Zhu XZ, Cai YF, Sun PY, Yang H, Wang XY, Li S, Wang D, Zhu HD.   +10 more
europepmc   +2 more sources