Results 51 to 60 of about 24,385 (266)

Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring

Journal of Animal Science and Biotechnology, 2021
Background Intrauterine growth restriction (IUGR) has negative impacts on the postnatal survival, growth and development of humans and animals, with not only on newborns but also adulthood.
Tiantian Li, Shimeng Huang, Long Lei, Shiyu Tao, Yi Xiong, Guoyao Wu, Jie Hu, Xiongkun Yuan, Shengjun Zhao, Bin Zuo, Hongjian Yang, Yingping Xiao, Gang Lin, Junjun Wang   +13 more
doaj   +1 more source

Dietary L-Arginine or N-Carbamylglutamate Alleviates Colonic Barrier Injury, Oxidative Stress, and Inflammation by Modulation of Intestinal Microbiota in Intrauterine Growth-Retarded Suckling Lambs

Antioxidants, 2022
Our previous studies have revealed that dietary N-carbamylglutamate (NCG) and L-arginine (Arg) supplementation improves redox status and suppresses apoptosis in the colon of suckling Hu lambs with intrauterine growth retardation (IUGR).
Hao Zhang, Yi Zheng, Xia Zha, Yi Ma, Xiaoyun Liu, Mabrouk Elsabagh, Hongrong Wang, Mengzhi Wang   +7 more
doaj   +1 more source

The impact of IUGR on pancreatic islet development and β-cell function

Journal of Endocrinology, 2017
Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR). IUGR increases the risk of developing type 2 diabetes mellitus (T2DM) throughout life, which indicates that insults from placental insufficiency impair β-cell ...
B. Boehmer, S. Limesand, P. Rozance
semanticscholar   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Metabolomic profile of umbilical cord blood plasma from early and late intrauterine growth restricted (IUGR) neonates with and without signs of brain vasodilation. [PDF]

PLoS ONE, 2013
ObjectivesTo characterize via NMR spectroscopy the full spectrum of metabolic changes in umbilical vein blood plasma of newborns diagnosed with different clinical forms of intrauterine growth restriction (IUGR).Methods23 early IUGR cases and matched 23 ...
Magdalena Sanz-Cortés, Rodrigo J Carbajo, Fatima Crispi, Francesc Figueras, Antonio Pineda-Lucena, Eduard Gratacós   +5 more
doaj   +1 more source

IUGR Is Associated With Marked Hyperphosphorylation of Decidual and Maternal Plasma IGFBP-1

Journal of Clinical Endocrinology and Metabolism, 2018
Context The mechanisms underpinning intrauterine growth restriction (IUGR), as a result of placental insufficiency, remain poorly understood, no specific treatment is available, and clinically useful biomarkers for early detection are lacking ...
Madhulika B. Gupta, Majida Abu Shehab, K. Nygard, K. Biggar, Sahil S Singal, N. Santoro, T. Powell, T. Jansson   +7 more
semanticscholar   +1 more source

Fetal Biometric Parameters in USG for Early Detection of Fetal Growth Restriction

Journal of Pharmacy and Bioallied Sciences
Background: Intrauterine growth restriction (IUGR) is a major pregnancy complication linked to adverse perinatal outcomes. Biometric parameters and Doppler velocimetry are valuable tools in diagnosing IUGR and predicting pregnancy outcomes.
Himanshy Rai, Shambhavi Soni, Amaresh K. Shukla, Mohita Pandey, Mayank P. Singh, Vishnu K. Gupta   +5 more
doaj   +1 more source

Postnatal pancreatic islet β cell function and insulin sensitivity at different stages of lifetime in rats born with intrauterine growth retardation. [PDF]

PLoS ONE, 2011
Epidemiological studies have linked intrauterine growth retardation (IUGR) to the metabolic diseases, consisting of insulin resistance, type 2 diabetes, obesity and coronary artery disease, during adult life.
Qingxin Yuan, Lu Chen, Cuiping Liu, Kuanfeng Xu, Xiaodong Mao, Chao Liu   +5 more
doaj   +1 more source

35 Individuals With HUWE1‐Related Neurodevelopmental Disorder and Suggested Clinical Evaluations

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT HUWE1 (HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase1, OMIM 300697), located at Xp11.22, encodes a ubiquitin ligase that is highly conserved across species. Genetic variants in HUWE1 described in multiple independent studies cause X‐linked intellectual disability, including in the patients identified by Juberg, Marsidi, and ...
Mindy H. Li, Deziree L. Coleman, Kelsey Hogan, Danielle Luz, Lindsay Bhandari, Newell Belnap, Tiffany Busa, Charles Coutton, Klaus Dieterich, Svetlana Gorokhova, Clara Hildebrandt, Rachel Logan, Milena Mariani, Manuela Morleo, Vincenzo Nigro, John Pappas, Rachel Rabin, Kelly Schoch, Angelo Selicorni, Vandana Shashi, Rebecca Spillmann, Jennifer Sullivan, Charlotte Tardy, Samantha A. Schrier Vergano, Brock Grill, Kristin Baranano   +25 more
wiley   +1 more source

IUGR impairs cardiomyocyte growth and maturation in fetal sheep

Journal of Endocrinology, 2018
Placental insufficiency causes intrauterine growth restriction (IUGR), a common complication of pregnancy. In skeletal muscle, IUGR reduces fetal myofibril size, reduces myoblast proliferation, and reduces expression of genes in cell cycle regulation ...
S. Jonker, Daniel Kamna, Dan LoTurco, J. Kailey, L. Brown   +4 more
semanticscholar   +1 more source