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L-Type Ca<sub>v</sub>1.3 and HCN Channels Mediate Heart Rate Acceleration by Catecholamines. [PDF]
Circ ResTorre E +18 more
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Abstract The cells of the sinoatrial (SA) node generate a cyclical change in their resting membrane potential that drives them towards the threshold that triggers an action potential. The spontaneous depolarization current is a combined Na+/K+ inward current, termed the Ifunny current (I(f)).
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Abstract The cells of the sinoatrial (SA) node generate a cyclical change in their resting membrane potential that drives them towards the threshold that triggers an action potential. The spontaneous depolarization current is a combined Na+/K+ inward current, termed the Ifunny current (I(f)).
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2016
Ivabradine is a blocker of the funny current channels in the sinoatrial node cells. This results in pure heart rate reduction when elevated without direct effect on contractility or on the vessels. It was tested in a large outcome clinical trial in stable chronic heart failure (CHF) with low ejection fraction, in sinus rhythm, on a contemporary ...
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Ivabradine is a blocker of the funny current channels in the sinoatrial node cells. This results in pure heart rate reduction when elevated without direct effect on contractility or on the vessels. It was tested in a large outcome clinical trial in stable chronic heart failure (CHF) with low ejection fraction, in sinus rhythm, on a contemporary ...
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Ivabradine: Cardiovascular Effects
Recent Patents on Cardiovascular Drug Discovery, 2009Ivabradine (a compound of the benzocyclobutane) is a highly selective I(f) current inhibitor acting directly on the sino-atrial node, induces a rapid, sustained and dose-dependent reduction of heart rate at rest and during exercise without a significant effect on atrio-ventricular conduction, left ventricular contraction/relaxation or vascular tissues.
Andrea, Rognoni +3 more
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