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Coronary artery bypass grafting may not be suitable in pure myocardial bridging: a case report. [PDF]
Eur Heart J Case RepYang TL, Hsu CC.
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Heart Rate Lowering With Ivabradine and Burden of Symptoms in Patients With Postural Orthostatic Tachycardia Syndrome. [PDF]
J Cardiovasc PharmacolMarchetta M +7 more
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Reactions Weekly, 2022
Abstract The cells of the sinoatrial (SA) node generate a cyclical change in their resting membrane potential that drives them towards the threshold that triggers an action potential. The spontaneous depolarization current is a combined Na+/K+ inward current, termed the Ifunny current (I(f)).
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Abstract The cells of the sinoatrial (SA) node generate a cyclical change in their resting membrane potential that drives them towards the threshold that triggers an action potential. The spontaneous depolarization current is a combined Na+/K+ inward current, termed the Ifunny current (I(f)).
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2016
Ivabradine is a blocker of the funny current channels in the sinoatrial node cells. This results in pure heart rate reduction when elevated without direct effect on contractility or on the vessels. It was tested in a large outcome clinical trial in stable chronic heart failure (CHF) with low ejection fraction, in sinus rhythm, on a contemporary ...
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Ivabradine is a blocker of the funny current channels in the sinoatrial node cells. This results in pure heart rate reduction when elevated without direct effect on contractility or on the vessels. It was tested in a large outcome clinical trial in stable chronic heart failure (CHF) with low ejection fraction, in sinus rhythm, on a contemporary ...
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Ivabradine: A Current Overview
Current Clinical Pharmacology, 2016Ivabradine, acting on the funny channel (If) in the sino-atrial node, reduces myocardial oxygen demand without inducing hypotension. It was developed as a specific bradycardic agent in the 1980s, avoiding the adverse effects of more traditional antianginal agents (beta-blockers and calcium channel antagonists).
Kaushik, Guha +3 more
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Ivabradine: Cardiovascular Effects
Recent Patents on Cardiovascular Drug Discovery, 2009Ivabradine (a compound of the benzocyclobutane) is a highly selective I(f) current inhibitor acting directly on the sino-atrial node, induces a rapid, sustained and dose-dependent reduction of heart rate at rest and during exercise without a significant effect on atrio-ventricular conduction, left ventricular contraction/relaxation or vascular tissues.
Andrea, Rognoni +3 more
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▼Ivabradine for stable angina?
Drug and Therapeutics Bulletin, 2008Up to 1 in 25 people in Europe and the USA have stable angina, with symptoms that may limit function and quality of life.1,2 Beta-blockers are usually used in initial symptomatic treatment, but may cause unwanted effects.3–6 They are also contraindicated in some patients (e.g.
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