Influencing factors analysis of clinical effect of heart failure patients treated with ivabradine and metoprolol succinate and construction and validation of nomogram prediction model. [PDF]
Wu G +8 more
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Long-term safety and efficacy of ivabradine after direct percutaneous coronary intervention in patients with acute myocardial infarction complicated by heart failure: a single-center retrospective study. [PDF]
Guo X +7 more
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A Prospective Clinical Audit to Improve Compliance With Perioperative Atrial Fibrillation Prevention Protocols in Off-Pump Coronary Artery Bypass Surgery. [PDF]
Rahman MZ +4 more
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Pharmacological interventions to enhance exercise capacity in patients with heart failure. [PDF]
Naito R.
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Pediatric Heart Failure Pharmacotherapy: Transformative Insights for the Future. [PDF]
Das BB.
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Myocardial Injury After Non-Cardiac Surgery in Otolaryngology: Evidence Gaps and a Systematic Review. [PDF]
Domka J +10 more
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Comparative cohort study of post-acute COVID-19 infection with a nested, randomized controlled trial of ivabradine for those with postural orthostatic tachycardia syndrome (the COVIVA study). [PDF]
Saunders D +19 more
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Abstract The cells of the sinoatrial (SA) node generate a cyclical change in their resting membrane potential that drives them towards the threshold that triggers an action potential. The spontaneous depolarization current is a combined Na+/K+ inward current, termed the Ifunny current (I(f)).
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Ivabradine is a blocker of the funny current channels in the sinoatrial node cells. This results in pure heart rate reduction when elevated without direct effect on contractility or on the vessels. It was tested in a large outcome clinical trial in stable chronic heart failure (CHF) with low ejection fraction, in sinus rhythm, on a contemporary ...
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