Results 51 to 60 of about 157,285 (342)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Reduced live birth rates in frozen versus fresh single cleavage stage embryo transfer cycles: A cross -sectional study

International Journal of Reproductive BioMedicine, 2020
Background: Studies have suggested that embryo-endometrial developmental asynchrony caused by slow-growing embryos can be corrected by freezing the embryo and transferring it back in a subsequent cycle.
Wan Tinn Teh, Alex Polyakov, Claire Garrett, David Edgar, John Mcbain, Peter Adrian Walton Rogers   +5 more
doaj   +1 more source

Multinucleation in the Two-Cell Stage Embryo Matters

Fertility & Reproduction, 2022
Background: Blastomere multinucleation (MN), defined as the presence of more than one nucleus per cell, in the cleavage-stage embryo, is a well-documented phenomenon1.
Leah LAZZARO, Martin HEALEY, Tiki OSIANLIS   +2 more
doaj   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

#159 : Aneuploidy Embryos Rate in Good Prognosis Patients After Fertilization Using ICSI and IMSI Methods

Fertility & Reproduction, 2023
Background and Aims: Embryo aneuploidy is caused by many factors, including patient age, sperm quality and sperm selection method. There are several methods for selecting sperm, ICSI (intracytoplasmic sperm injection) and IMSI (intracytoplasmic ...
Reza Raharjo, Arief Boediono, Ivan Sini, Wahyu Indrasari   +3 more
doaj   +1 more source

Various Faces of Type IIA Supergravity

, 2003
We derive a duality-symmetric action for type IIA D=10 supergravity by the Kaluza-Klein dimensional reduction of the duality-symmetric action for D=11 supergravity with the 3-form and 6-form gauge field.
Aganagic, Aganagic, Aganagic, Alexei J. Nurmagambetov, Bandos, Bandos, Bandos, Bandos, Bandos, Bandos, Bandos, Bandos, Bandos, Bekaert, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bonora, Campbell, Cariglia, Cederwall, Cederwall, Chamseddine, Chamseddine, Cremmer, Cremmer, Dall'Agata, Dall'Agata, Dall'Agata, de Azcárraga, Delduc, Dmitri P. Sorokin, Freed, Galperin, Gianni, Green, Green, Huq, Igor A. Bandos, Kalkkinen, Lavrinenko, Lechner, Lechner, Lechner, Lechner, Lechner, Lü, Naito, Nurmagambetov, Nurmagambetov, Pasti, Pasti, Pasti, Pasti, Polchinski, Romans, Sato, Schwarz, Schwarz, Sorokin, Townsend, Witten, Witten, Zheltukhin, Zheltukhin   +71 more
core   +1 more source

A ‘healthy baby’: The double imperative of preimplantation genetic diagnosis [PDF]

, 2010
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 The Authors.This article reports from a study exploring the social processes, meanings and institutions that frame and produce ...
Casper, M.J., Chambliss, D., Clare Williams, Foucault, M., Grint, K., Kathryn Ehrich, Lofland, J., Quintavalle, J., Thompson, C., Williams, C.   +9 more
core   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF [PDF]

, 2016
STUDY QUESTION. Are significant abnormalities in outward (K+) conductance and resting membrane potential (Vm) present in the spermatozoa of patients undertaking IVF and ICSI and if so, what is their functional effect on fertilization success?
Barratt, Christopher L. R., Brown, Sean G., Lishko, Polina V., Mansell, Steven A., Martins da Silva, Sarah, Publicover, Stephen J., Ramalingam, Mythili, Sutton, Keith A., Williams, Hannah L., Wilson, Stuart M.   +9 more
core   +6 more sources

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source