Results 51 to 60 of about 41,297,516 (316)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Boundary Value Problems, 2017 This article deals with integral boundary value problems of the second-order differential equations { u ″ ( t ) + a ( t ) u ′ ( t ) + b ( t ) u ( t ) + f ( t , u ( t ) ) = 0 , t ∈ J + , u ( 0 ) = ∫ 0 1 g ( s ) u ( s ) d s , u ( 1 ) = ∫ 0 1 h ( s ) u ( s )
Qiuyan Zhong, Xingqiu Zhang
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Scientific ReportsThis study presents a computational fluid dynamics (CFD) analysis of heat transfer and pressure drop in a straight slot impingement jet, utilizing $$\:\text{T}\text{i}{\text{O}}_{2}/{\text{H}}_{2}\text{O}$$ nanofluid within a square duct.
Anil Kumar +8 more
doaj +1 more source
“The World, More or Less” by Jean Rouaud: between novel and autofiction
RUDN Journal of Studies in Literature and Journalism, 2019 This article discusses theoretical approaches to autofiction - a new form of self-writing which spread in French literature from the 80s. The analysis of the autofictional device implemented in the novel “The World, More or Less” by Jean Rouaud produces ...
Gérard Siary, Yulia Anatolievna Kosova
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Auch wir lieben bekanntermaßen Daten. Daher ist Text+ natürlich auch bei der diesjährigen Love Data Week dabei, die vom 12. bis 16. Februar stattfindet.
Text+ Blog-Redaktion
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Estimating ecosystem maximum light use efficiency based on the water use efficiency principle
Environmental Research Letters, 2021 Light use efficiency (LUE) defines the vegetation efficiency of converting radiative energy into biochemical energy through photosynthesis. Estimating the maximum LUE ( ε _max ) is critical yet challenging for quantifying gross primary production (GPP ...
Rong Gan +10 more
doaj +1 more source
Text+ auf der OPERAS-Konferenz 2024
Autor:innen: Nanette Rißler-Pipka, Angela Vorndran, Philippe Genêt, Eva-Maria Gerstner Bei der kommenden OPERAS conference 2024, die vom 24. bis zum 26.
Text+ Mitglied
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