Results 61 to 70 of about 41,297,516 (316)

Structure and access : the role of structural factors in text comprehension and information [PDF]

, 1985
In this thesis it is argued that structural factors play an important role in facilitating the access, comprehension, and recall of textual information, especially when the content of the material is unfamiliar to the reader.
O'Malley, C.E, O'Malley, Claire E.
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Text+ goes BiblioCon 2024

Bei der BiblioCon 2024, die unter dem Thema "offen.lokal.global." Anfang Juni in Hamburg veranstaltet wird, ist Text+ mit mehreren Beiträgen vertreten. Die BiblioCon (ehemals "Bibliothekartag") ist die zentrale Tagung des deutschen Bibliothekswesens, die
Text+ Blog-Redaktion
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Text+ Plenary 2024: Call for Posters

Das 3. Plenary von Text+ widmet sich am 10.+11. Oktober 2024 dem Thema „Large Language Models (LLMs) und deren Nutzung“. Für diejenigen, die sich bisher nicht mit den Hintergründen von LLMs beschäftigt haben, gibt es die Möglichkeit, am Nachmittag vor ...
Text+ Blog-Redaktion
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

2. Text+/RIDE-Band zu FAIRen Editionen veröffentlicht

Autor: Text+ Redaktion Wir freuen uns, ankündigen zu können, dass der zweite Teil des zweiten gemeinsamen RIDE Bandes von Text+ und dem Institut für Dokumentologie und Editorik e.V. (IDE) veröffentlicht wurde.
Text+ Blog-Redaktion
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Particle Circulation Modeling of a Bulkhead-Mounted J-Type Loop Seal in a Circulating Fluidized Bed

Journal of Chemical Engineering of Japan
To realize flexible heat integration among several reactions, a bench-scale three-compartment circulating fluidized bed (CFB) system integrating internal J- and L-Type loop seals aimed at developing.
Cai Wanxuan, Reiji Noda
doaj   +1 more source