Results 81 to 90 of about 57,951,730 (260)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Bei der BiblioCon 2024, die unter dem Thema "offen.lokal.global." Anfang Juni in Hamburg veranstaltet wird, ist Text+ mit mehreren Beiträgen vertreten. Die BiblioCon (ehemals "Bibliothekartag") ist die zentrale Tagung des deutschen Bibliothekswesens, die
Text+ Blog-Redaktion
core +1 more source
Particle Circulation Modeling of a Bulkhead-Mounted J-Type Loop Seal in a Circulating Fluidized Bed
Journal of Chemical Engineering of JapanTo realize flexible heat integration among several reactions, a bench-scale three-compartment circulating fluidized bed (CFB) system integrating internal J- and L-Type loop seals aimed at developing.
Cai Wanxuan, Reiji Noda
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Some Remarks on the Annihilating-Ideal Graph of Commutative Ring with Respect to an Ideal [PDF]
Mathematics Interdisciplinary ResearchThe graph $ AG ( R ) $ {of} a commutative ring $R$ with identity has an edge linking two unique vertices when the product of the vertices equals {the} zero ideal and its vertices are the nonzero annihilating ideals of $R$.The annihilating-ideal graph ...
Zahra Mahmudiankoruie +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Readability score benchmark of the pre- and post-hypernym substituted text using the GPT-J-6B approach for text simplification.
Karl Swanson (3580583) +9 more
core +1 more source